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Title: Melatonin attenuates stress-induced defecation: Lesson from a rat model of stress-induced gut dysfunction
Authors: Song, G.H. 
Gwee, K.A. 
Moochhala, S.M. 
Ho, K.Y.
Keywords: Corticotropin-releasing factor
Issue Date: Oct-2005
Citation: Song, G.H., Gwee, K.A., Moochhala, S.M., Ho, K.Y. (2005-10). Melatonin attenuates stress-induced defecation: Lesson from a rat model of stress-induced gut dysfunction. Neurogastroenterology and Motility 17 (5) : 744-750. ScholarBank@NUS Repository.
Abstract: Melatonin is known to alleviate stress and modulate gut motility. We investigated the modulating effects of melatonin on stress-induced gut dysfunction. One hundred Wistar rats were randomly assigned to five equal groups, receiving intraperitoneal injections of 0, 1, 10, 100 or 1000 μg kg-1 melatonin, respectively. Fifteen minutes later, each group was divided again into four subgroups receiving no treatment, 0.25 mg luzindole (a non-selective melatonin receptor antagonist) intraperitoneally, wrap-restraint stress, and 10 mg kg-1 serotonin intraperitoneally, respectively. Two hours later, serum serotonin, corticotropin-releasing factor (CRF) and melatonin levels, and faecal output were recorded. Results showed that intraperitoneal melatonin increased faecal output, but this effect was abolished by luzindole. In wrap-restraint group, prior intraperitoneal melatonin at doses of 100 or 1000 μg kg-1 significantly inhibited stress-induced defecation. This effect was associated with corresponding reductions in serum serotonin and CRF concentrations. In serotonin-treated group, serotonin-induced defecation was also inhibited by melatonin. In conclusion, melatonin exhibited an excitatory effect on bowel output in rats placed under resting state, while attenuated defecation in those subjected to wrap-restraint stress or serotonin treatment. The inhibitory effects of melatonin on stress-induced defecation may stem from its antagonistic effect on stress-induced enhancement of serotonin and CRF secretion. © 2005 Blackwell Publishing Ltd.
Source Title: Neurogastroenterology and Motility
ISSN: 13501925
Appears in Collections:Staff Publications

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