Please use this identifier to cite or link to this item:
|Title:||Prophylactic strategies for Hepatitis B patients undergoing liver transplant: A cost-effectiveness analysis||Authors:||Dan, Y.Y.
|Issue Date:||May-2006||Citation:||Dan, Y.Y., Wai, C.T., Yeoh, K.G., Lim, S.G. (2006-05). Prophylactic strategies for Hepatitis B patients undergoing liver transplant: A cost-effectiveness analysis. Liver Transplantation 12 (5) : 736-746. ScholarBank@NUS Repository.||Abstract:||Hepatitis B immunoglobulin with lamivudine prophylaxis (LAM/HBIG) is effective in preventing Hepatitis B (HBV) recurrence posttransplant but is expensive and inconvenient. Lamivudine-resistant HBV, which has limited the usefulness of lamivudine monoprophylaxis in transplant, can now be effectively controlled with adefovir dipivoxil. We performed a cost-effectiveness analysis on the strategies of lamivudine prophylaxis with adefovir rescue(LAM/ADV) compared to combination LAM/intravenous fixed high-dose HBIG prophylaxis(LAM/ivHBIG) or LAM/intramuscular HBIG prophylaxis(LAM/imHBIG). Markov modeling was performed with analysis from societal perspective. Probability rates were derived from systematic review of the literature and cost taken from MEDICARE database. Outcome measures were incremental cost-effectiveness ratio(ICER) and cost to prevent each HBV recurrence and death. Analysis was performed at 5 years posttransplant as well as at end of life expectancy (15 years). Combination LAM/ivHBIG cost an additional USD562,000 at 15 years, while LAM/imHBIG cost an additional USD139,000 per patient compared to LAM/ADV. Although there is an estimated increase in recurrence of 53% with LAM/ADV and 7.6% increased mortality at the end of life expectancy (15 years), the ICER of LAM/ivHBIG over LAM/ADV treatment is USD760,000 per quality-adjusted life-years and for LAM/ imHBIG, USD188,000. Cost-effectiveness is most sensitive to cost of HBIG. Lamivudine prophylaxis with adefovir dipivoxil salvage offers the more cost-effective option for HBV patients undergoing liver transplant but with higher recurrence and death rate using a model that favors LAM/ HBIG. Lowering the cost of HBIG maintenance will improve cost-effectiveness of LAM/HBIG strategy. In conclusion, a tailored approach based on individual risks will optimize the cost-benefit of HBV transplant prophylaxis. © 2006 AASLD.||Source Title:||Liver Transplantation||URI:||http://scholarbank.nus.edu.sg/handle/10635/131538||ISSN:||15276465|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on May 11, 2018
WEB OF SCIENCETM
checked on Dec 19, 2018
checked on Jun 13, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.