Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/131537
Title: Interleukin-18 promoter gene polymorphisms in Chinese patients with systemic lupus erythematosus: Association with CC genotype at position -607
Authors: Xu, Q.
Soe, K.T.
Paramalingam, S.S.
Thumboo, J. 
Koh, D.-R.
Fong, K.-Y. 
Keywords: Cytokines
Genotype
Single nucleotide polymorphisms
Issue Date: Feb-2007
Citation: Xu, Q., Soe, K.T., Paramalingam, S.S., Thumboo, J., Koh, D.-R., Fong, K.-Y. (2007-02). Interleukin-18 promoter gene polymorphisms in Chinese patients with systemic lupus erythematosus: Association with CC genotype at position -607. Annals of the Academy of Medicine Singapore 36 (2) : 91-95. ScholarBank@NUS Repository.
Abstract: Introduction: Interleukin-18 (IL-18) is a Th1 cytokine, which is postulated to play a role in systemic lupus erythematosus (SLE). Two single nucleotide polymorphisms (SNPs) in the IL-18 promoter gene region were found to influence the quantitative expression of the IL-18 protein. The aim of this study was to determine whether IL-18 promoter gene polymorphisms are associated with SLE. Materials and Methods: One hundred and thirteen Chinese SLE patients and 218 Chinese healthy individuals were recruited. Genomic DNA was extracted from peripheral venous blood. Sequence-specific primer PCR and restriction fragment length polymorphism (RFLP) analysis were used to genotype the DNA samples for SNP-137 and SNP-607. The following genotypes were obtained: SNP(-607) AA, AC, CC and SNP(-137) GG, GC, CC. Plasma IL-18 concentrations of patients and control subjects were measured by enzyme-linked immunosorbent assay. Results: the frequency of SNP-607/CC genotype was significantly higher in SLE patients (Pc < 0.05) while genotype SNP-607/AC was significantly decreased in SLE patients compared to the control group (Pc
Source Title: Annals of the Academy of Medicine Singapore
URI: http://scholarbank.nus.edu.sg/handle/10635/131537
ISSN: 03044602
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