Please use this identifier to cite or link to this item: https://doi.org/10.1378/chest.128.1.424
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dc.titleInhalational nickel carbonyl poisoning in waste processing workers
dc.contributor.authorSeet, R.C.S.
dc.contributor.authorJohan, A.
dc.contributor.authorTeo, C.E.S.
dc.contributor.authorGan, S.L.
dc.contributor.authorLee, K.H.
dc.date.accessioned2016-11-29T01:19:35Z
dc.date.available2016-11-29T01:19:35Z
dc.date.issued2005-07
dc.identifier.citationSeet, R.C.S., Johan, A., Teo, C.E.S., Gan, S.L., Lee, K.H. (2005-07). Inhalational nickel carbonyl poisoning in waste processing workers. Chest 128 (1) : 424-429. ScholarBank@NUS Repository. https://doi.org/10.1378/chest.128.1.424
dc.identifier.issn00123692
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131518
dc.description.abstractBackground: Nickel carbonyl is formed when carbon monoxide comes into contact with active nickel. The inhaled nickel carbonyl is rapidly absorbed and distributed mainly to the lungs, brain, adrenal glands, and kidneys. In severe cases, acute nickel carbonyl exposure has been reported to cause death. Design: Descriptive study. Patients: Seven young men presented with fever, chills, substernal pleuritic chest pain, and exertional dyspnea. Extensive microbiological and toxicological investigations (including blood, urine, and bronchial specimens) for known pathogens and occupational toxins were performed. The clinical course and radiologic findings of each patient, including autopsy findings of three patients who died, were described. Results: Four patients received treatment in the ICU. Elevated urinary nickel concentration was detected in all patients. Results of extensive microbiological investigations were unremarkable. No patients received chelating agents. Pulmonary consolidation, edema, hemorrhage, and fibrosis were observed at autopsy in patients who died. An out-of-date chemical used during neutralization of nickel waste was implicated as the source of nickel carbonyl poisoning. Conclusions: High mortality was reported in patients who presented subacutely following nickel carbonyl exposure. Further studies should be performed to clarify the role of chelation therapy in the subacute phases following nickel carbonyl exposure.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1378/chest.128.1.424
dc.sourceScopus
dc.subjectChelation therapy
dc.subjectClinical features
dc.subjectNickel carbonyl
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.description.doi10.1378/chest.128.1.424
dc.description.sourcetitleChest
dc.description.volume128
dc.description.issue1
dc.description.page424-429
dc.description.codenCHETB
dc.identifier.isiut000230530500064
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