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https://scholarbank.nus.edu.sg/handle/10635/131424
| Title: | Novel brain reactive autoantibodies: Prevalence in systemic lupus erythematosus and association with psychoses and seizures | Authors: | Tin, S.K. Xu, Q. Thumboo, J. Lee, L.Y. Tse, C. Fong, K.Y.{14758} |
Keywords: | Brain reactive autoantibodies Neuropsychiatric lupus Psychosis Seizures |
Issue Date: | Dec-2005 | Citation: | Tin, S.K., Xu, Q., Thumboo, J., Lee, L.Y., Tse, C., Fong, K.Y.{14758} (2005-12). Novel brain reactive autoantibodies: Prevalence in systemic lupus erythematosus and association with psychoses and seizures. Journal of Neuroimmunology 169 (1-2) : 153-160. ScholarBank@NUS Repository. | Abstract: | Autoantibodies can cause neuropsychiatric manifestations in lupus patients by altering the physiological function of neuronal cells. In this study, we identified Brain Reactive Autoantibodies (BRAAs) against murine neuronal membrane proteins (M.W. 27.5 and 29.5 kD) and found them correlating with psychosis and/or seizures in lupus patients. They were specific to neuronal membrane tissues of mammalian origin and are significantly associated with psychosis and/or seizures (p < 0.0001). These membrane proteins mass spectrometry profiles did not match to any published protein sequences. These BRAAs may play important roles in the pathophysiology of neuropsychiatric lupus. © 2005 Elsevier B.V. All rights reserved. | Source Title: | Journal of Neuroimmunology | URI: | http://scholarbank.nus.edu.sg/handle/10635/131424 | ISSN: | 01655728 |
| Appears in Collections: | Staff Publications |
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