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Title: Parkinsonism as an unusual presenting symptom of pineal gland teratoma
Authors: Dolendo, M.C.J. 
Lin, T.P.
Tat, O.H.
Chong, Q.T. 
Timothy, L.K.Y. 
Issue Date: Apr-2003
Citation: Dolendo, M.C.J., Lin, T.P., Tat, O.H., Chong, Q.T., Timothy, L.K.Y. (2003-04). Parkinsonism as an unusual presenting symptom of pineal gland teratoma. Pediatric Neurology 28 (4) : 310-312. ScholarBank@NUS Repository.
Abstract: We report a case of a 14-year-old Chinese boy with immature teratoma of the pineal gland who manifested with parkinsonism. Diagnostic evaluation revealed hydrocephalus and an immature teratoma of the pineal gland extending to the thalamus. An urgent ventriculoperitoneal shunt was inserted, and chemotherapy was given to reduce the tumor size. The tumor was completely excised 2 months after diagnosis with improvement of clinical signs and symptoms. His symptoms recurred 3 months later with sudden onset of obtundation, tremors, cogwheel rigidity, and marked bradykinesia. Magnetic resonance imaging (MRI) revealed a small enhancing lesion in the pineal region and progressive hydrocephalus on serial studies. He was treated with carbidopa/levodopa and amantadine, but marked improvement was only observed after reprogramming his VP shunt. Features consistent with the growing teratoma syndrome were noted during this period. These were progressive pineal gland tumor enlargement documented on MRI without increase in previously elevated alpha-fetoprotein levels. The tumor continued to enlarge despite gamma knife radiosurgery. Secondary parkinsonism is a rare presentation of pineal gland tumors and has not been reported in association with the growing teratoma syndrome. © 2003 by Elsevier Inc. All rights reserved.
Source Title: Pediatric Neurology
ISSN: 08878994
DOI: 10.1016/S0887-8994(02)00620-3
Appears in Collections:Staff Publications

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