Please use this identifier to cite or link to this item: https://doi.org/10.1515/JPM.2004.023
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dc.titleOxytocic activity of thrombin: Modulation of thrombin-induced gravid rat myometrial contractions by 5-hydroxytryptamine receptor antagonists
dc.contributor.authorAdebiyi, A.
dc.contributor.authorAdaikan, G.P.
dc.contributor.authorPrasad, R.N.V.
dc.date.accessioned2016-11-28T10:18:56Z
dc.date.available2016-11-28T10:18:56Z
dc.date.issued2004
dc.identifier.citationAdebiyi, A., Adaikan, G.P., Prasad, R.N.V. (2004). Oxytocic activity of thrombin: Modulation of thrombin-induced gravid rat myometrial contractions by 5-hydroxytryptamine receptor antagonists. Journal of Perinatal Medicine 32 (2) : 126-131. ScholarBank@NUS Repository. https://doi.org/10.1515/JPM.2004.023
dc.identifier.issn03005577
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131330
dc.description.abstractBackground: Thrombin possesses potent oxytocic activity in vitro and in vivo. This activity has been proposed to play a role in post-parturitional uterine contractions and possibly, preterm birth related to intrauterine hemorrhage. Previous workers have demonstrated that cyclo-oxygenase pathway may not play a significant role in oxytocic activity of thrombin. However, the role of 5-hydroxytryptamine (a mediator of some of the biological activities of thrombin) in the oxytocic activity of thrombin is unknown. The present study therefore aimed to examine the possible involvement of 5-hydroxytryptamine in thrombin-induced myometrial contractions. Methods: Effect of 5-hydroxytryptamine receptor antagonists on thrombin-induced contractions of isolated gravid rat myometrium was studied using isolated tissue bath system. Results: Thrombin-induced myometrial contractions were significantly and concentration-dependently inhibited by ketanserin and methysergide. Furthermore, 12±2% increase in the force of contractions of gravid rat myometrium pre-contracted with 5-hydroxytryptamine (1 μM) was provoked by 1 U/ml of thrombin. Thrombin-induced augmentation of the uterine stimulating effect of 5-hydroxytryptamine was characterized by pronounced increase in the contractile tone. Conclusions: 5-hydroxytryptamine may possibly play a role in oxytocic activity of thrombin. Uterine hyperactivity associated with intrauterine hemorrhage could hence involve thrombin-induced 5-hydroxytryptamine production in the uterus.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1515/JPM.2004.023
dc.sourceScopus
dc.subject5-hydroxytryptamine
dc.subjectKetanserin
dc.subjectMethysergide
dc.subjectMyometrial contractions
dc.subjectOxytocic activity
dc.subjectThrombin
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.description.doi10.1515/JPM.2004.023
dc.description.sourcetitleJournal of Perinatal Medicine
dc.description.volume32
dc.description.issue2
dc.description.page126-131
dc.description.codenJPEMA
dc.identifier.isiut000220367700004
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