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Title: Histaminergic effect of crude papaya latex on isolated guinea pig ileal strips
Authors: Adebiyi, A.
Adaikan, P.G. 
Prasad, R.N.V. 
Keywords: Contraction
Crude papaya latex
Extracellular Ca 2+
H 1-receptors
Ileal strips
Issue Date: Jan-2004
Citation: Adebiyi, A., Adaikan, P.G., Prasad, R.N.V. (2004-01). Histaminergic effect of crude papaya latex on isolated guinea pig ileal strips. Phytomedicine 11 (1) : 65-70. ScholarBank@NUS Repository.
Abstract: In the present study, we investigated the effect of the crude latex of Carica papaya L. (CPX) on isolated guinea pig ileal strips. CPX (0.5-512 μg/ml) caused concentration-dependent contraction of ileal strips suspended in Tyrode solution. The concentration of atropine (0.69 μM) that significantly blocked the contractile effect of acetylcholine on the isolated guinea pig ileum showed no significant effect on CPX- and histamine-induced contractions of the ileal strips. Mepyramine (87.6 nM) significantly blocked the contractile effect of histamine and CPX on the ileum. The same concentration of mepyramine, however, had no significant effect on acetylcholine-induced contraction of the isolated ileal strips. Removal of Ca 2+ from the bathing medium abolished ileal contractions induced by acetylcholine, histamine and CPX. All the test substances were able to provoke ileal contractions after replacement of the Ca 2+-free solution with Tyrode solution. Furthermore, 10 -5 M of nifedipine, a Ca 2+-entry antagonist, reversibly inhibited the contractile effect of all the test substances on the ileal strips. Results of this study together appear to show that CPX-induced contraction of the isolated guinea pig ileum is mediated via H 1-receptors and dependent on extracellular Ca 2+ influx.
Source Title: Phytomedicine
ISSN: 09447113
Appears in Collections:Staff Publications

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