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Title: Possible protective role of HLA-B(*)2706 for ankylosing spondylitis
Authors: Ren, E.C. 
Koh, W.H.
Sim, D.
Boey, M.L.
Wee, G.B.
Chan, S.H. 
Keywords: Ankylosing spondylitis
DNA typing
Issue Date: 1997
Citation: Ren, E.C., Koh, W.H., Sim, D., Boey, M.L., Wee, G.B., Chan, S.H. (1997). Possible protective role of HLA-B(*)2706 for ankylosing spondylitis. Tissue Antigens 49 (1) : 67-69. ScholarBank@NUS Repository.
Abstract: HLA-B27 is strongly associated with ankylosing spondylitis (AS) but the role of the HLA molecule itself is still unclear. In this study on Singapore Chinese, we have subtyped 50 B27 positive AS patients and 45 B27 positive normals and found that the B*2706 allele has a significant negative association with disease (p = 0.047). Together with recent data indicating the existence of AS 'protective' B27 alleles, our data shows that the HLA molecule itself plays a crucial role in disease development.
Source Title: Tissue Antigens
ISSN: 00012815
Appears in Collections:Staff Publications

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