Please use this identifier to cite or link to this item: https://doi.org/10.1016/0198-8859(95)00085-2
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dc.titleInfluence of gender and age at onset on the HLA associations in Chinese with insulin-dependent diabetes mellitus
dc.contributor.authorChan, S.H.
dc.contributor.authorThai, A.C.
dc.contributor.authorLin, Y.N.
dc.contributor.authorLiu, K.F.
dc.contributor.authorWee, G.B.
dc.date.accessioned2016-11-28T10:18:24Z
dc.date.available2016-11-28T10:18:24Z
dc.date.issued1995
dc.identifier.citationChan, S.H., Thai, A.C., Lin, Y.N., Liu, K.F., Wee, G.B. (1995). Influence of gender and age at onset on the HLA associations in Chinese with insulin-dependent diabetes mellitus. Human Immunology 44 (3) : 175-180. ScholarBank@NUS Repository. https://doi.org/10.1016/0198-8859(95)00085-2
dc.identifier.issn01988859
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131283
dc.description.abstractIDDM in Singaporean Chinese was associated with HLA B58, DRB1*0301, DQB1*0201, and joint occurrences of DRB1*0301/*0901 and DRB1*0301/*04. Of the DR4s the frequencies of DRB1*0401, *0404, and *0405 were higher and *0406 was lower in patients compared to controls. DRB*0301/*0901 was observed mainly in female patients and the frequency showed an inverse relationship with age at onset, whereas DRB1*0301/*04 was observed mainly in male patients and also showed an inverse relationship with age at onset. DRB1*1202 showed an increasing frequency with age at onset. IDDM patients had a higher frequency of homozygous NAsp57 DQβ chains and a lower frequency of homozygous Asp57 DQβ chains compared to controls, especially in younger onset patients.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/0198-8859(95)00085-2
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY
dc.contributor.departmentMEDICINE
dc.contributor.departmentWHO IMMUNOLOGY RESEARCH & TRAINING CTR
dc.description.doi10.1016/0198-8859(95)00085-2
dc.description.sourcetitleHuman Immunology
dc.description.volume44
dc.description.issue3
dc.description.page175-180
dc.description.codenHUIMD
dc.identifier.isiutA1995TK54100007
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