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Title: Intermedilysin release by Streptococcus intermedius: Effects of various antibacterial drugs at sub-MIC levels
Authors: Taylor, M.B. 
Oh, J.H.L.
Kang, K.L.
Chow, V.T.K. 
Keywords: Intermedilysin
Streptococcus intermedius
Sub-minimum inhibitory concentration
Issue Date: 15-Feb-2005
Citation: Taylor, M.B., Oh, J.H.L., Kang, K.L., Chow, V.T.K. (2005-02-15). Intermedilysin release by Streptococcus intermedius: Effects of various antibacterial drugs at sub-MIC levels. FEMS Microbiology Letters 243 (2) : 379-384. ScholarBank@NUS Repository.
Abstract: Intermedilysin is a cytolytic toxin produced by Streptococcus intermedius, a pathogen of humans. In vitro studies showed that exposure of S. intermedius to sub-minimum inhibitory concentration (MIC) levels (1/2 MIC) of protein-inhibiting antibiotics and nucleic acid-inhibiting antibiotics decreased intermedilysin release by S. intermedius. The most potent antibiotic was clindamycin. On the other hand, exposure to cell wall-inhibiting antibiotics generally showed insignificant changes in intermedilysin release at sub-MIC concentrations. Investigations into possible mechanisms underlying this sub-MIC effect with clindamycin showed that there was selective decrease in biosynthesis and release of toxin after exposure to 1/2 MIC condition. However, no significant differences in the mRNA levels of the intermedilysin gene were observed. © 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
Source Title: FEMS Microbiology Letters
ISSN: 03781097
DOI: 10.1016/j.femsle.2004.12.028
Appears in Collections:Staff Publications

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