Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/131254
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dc.titleInhibition of staphylococcal enterotoxin-driven lymphocyte proliferation by anti-MHC class II monoclonal antibody
dc.contributor.authorLoh, M.-T.
dc.contributor.authorSrinivasan, N.
dc.contributor.authorChan, S.-H.
dc.contributor.authorRen, E.-C.
dc.date.accessioned2016-11-28T10:18:03Z
dc.date.available2016-11-28T10:18:03Z
dc.date.issued1995
dc.identifier.citationLoh, M.-T., Srinivasan, N., Chan, S.-H., Ren, E.-C. (1995). Inhibition of staphylococcal enterotoxin-driven lymphocyte proliferation by anti-MHC class II monoclonal antibody. Hybridoma 14 (5) : 429-433. ScholarBank@NUS Repository.
dc.identifier.issn0272457X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131254
dc.description.abstractStaphylococcal enterotoxins (SE) bind to major histocompatibility complex (MHC) class II molecules and the Vβ region of T cell receptors (TCR) and subsequently induces T cell proliferation. This mitogenicity is the basis of pathological effects seen in food poisoning and toxic shock syndrome. Toxin- specific monoclonal antibodies have previously been shown to be effective in blocking toxin stimulated T cell responses. In this study, a monoclonal antibody, 52BL1, was found to be a potent inhibitor of SEA-, SEB-, SEC1-, SED-, and SEE-induced lymphocyte proliferation assays, which indicates that a single anti-HLA (human leukocyte antigen) class II antibody is effective in blocking the biological effects of these toxins. These results demonstrate the possibility of using anti-HLA class II antibodies in a clinical setting as an antagonist to staphylococcal enterotoxin-mediated pathogenesis.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY
dc.description.sourcetitleHybridoma
dc.description.volume14
dc.description.issue5
dc.description.page429-433
dc.description.codenHYBRD
dc.identifier.isiutNOT_IN_WOS
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