Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0165-0327(99)00104-4
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dc.titleNegative association between T102C polymorphism at the 5-HT2A receptor gene and bipolar affective disorders in Singaporean Chinese
dc.contributor.authorTut, T.G.
dc.contributor.authorWang, J.L.
dc.contributor.authorLim, C.C.L.
dc.date.accessioned2016-11-28T10:17:52Z
dc.date.available2016-11-28T10:17:52Z
dc.date.issued2000-06
dc.identifier.citationTut, T.G., Wang, J.L., Lim, C.C.L. (2000-06). Negative association between T102C polymorphism at the 5-HT2A receptor gene and bipolar affective disorders in Singaporean Chinese. Journal of Affective Disorders 58 (3) : 211-214. ScholarBank@NUS Repository. https://doi.org/10.1016/S0165-0327(99)00104-4
dc.identifier.issn01650327
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131240
dc.description.abstractBackground: Serotonergic system abnormalities have been implicated in the pathogenesis of bipolar affective disorders. The 5-hydroxytryptamine type 2A (5HTR2A) receptor gene located on chromosome 13 (13q14-21) can be considered as a candidate gene for bipolar affective disorder (BPAD). Methods: Seventy-two patients with BPAD and 74 normal population controls were genotyped with restriction fragment length polymorphism (RFLP) in the 5HTR2A receptor gene. Results: We report a negative association between 5HTR2A receptor gene and BPAD. The association was examined using a case-control design. Allele and genotype frequencies as well as homozygote-heterozygote distribution at the 5HTR2A receptor gene polymorphism were compared between the two groups. There were no significant differences in the allelic or genotype frequencies and the homozygote-heterozygote distributions. Limitations: Patients were recruited from one hospital in Singapore. The case-control study design needs replication. Conclusion: Our finding indicates that the 5HTR2A receptor gene polymorphism is not a major factor in the genetic susceptibility to BPAD in Singaporean Chinese. Copyright (C) 2000 Elsevier Science B.V.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0165-0327(99)00104-4
dc.sourceScopus
dc.subject5-HT2A receptor gene
dc.subjectBipolar affective disorder
dc.subjectChinese
dc.subjectSerotonin
dc.subjectSingapore
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.contributor.departmentPSYCHOLOGICAL MEDICINE
dc.description.doi10.1016/S0165-0327(99)00104-4
dc.description.sourcetitleJournal of Affective Disorders
dc.description.volume58
dc.description.issue3
dc.description.page211-214
dc.description.codenJADID
dc.identifier.isiut000087287900004
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