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|Title:||Klebsiella bacteraemia: a report of 101 cases from National University Hospital, Singapore||Authors:||Lee, K.H.
|Issue Date:||Aug-1994||Citation:||Lee, K.H., Hui, K.P., Tan, W.C., Lim, T.K. (1994-08). Klebsiella bacteraemia: a report of 101 cases from National University Hospital, Singapore. Journal of Hospital Infection 27 (4) : 299-305. ScholarBank@NUS Repository.||Abstract:||One hundred and one cases of Klebsiella bacteraemia from the National University Hospital, Singapore, were reviewed retrospectively. There were 54 (53·5%) males and 47 (46·5%) females. Mean (± £se) age was 54 (± 2·4) years. Overall mortality was 26%. Nosocomial infections accounted for 20%. Underlying diabetes mellitus and malignancy were present in 36 and 26% respectively. The source of the bacteraemia was not known in 33% of cases, 17% had liver abscess, 29% had urinary tract infections, 9% had pneumonia, 10% had an abscess separate from the liver, and 3% had biliary sepsis. Elevated alkaline phosphatase (> 100 U-) was seen in all cases of liver abscess (sensitivity 100%, specificity 27%). Nonsurvivors had a significantly lower platelet count than survivors (104± 25 × 109/1 vs. 176 ± 15 × 109/1, unpaired t-test P < 0·05), and a platelet count of less than 150 × 109/1 was associated with a significantly higher mortality (37% vs. 11%, χ2 P < 0·01). Nosocomial infection was associated with 45% mortality, whereas community-acquired infection had a lower rate of 21%, this was not statistically significant. Seventy-eight per cent of these Klebsiella isolates were sensitive to gentamicin and cotrimoxazole, and 100% to imipenem. © 1994.||Source Title:||Journal of Hospital Infection||URI:||http://scholarbank.nus.edu.sg/handle/10635/131205||ISSN:||01956701|
|Appears in Collections:||Staff Publications|
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