Please use this identifier to cite or link to this item: https://doi.org/10.1053/jcan.2002.126945
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dc.titlePrediction of excessive bleeding after coronary artery bypass graft surgery: The influence of timing and heparinase on thromboelastography
dc.contributor.authorTi, L.K.
dc.contributor.authorCheong, K.-F.
dc.contributor.authorChen, F.-G.
dc.date.accessioned2016-11-28T10:17:01Z
dc.date.available2016-11-28T10:17:01Z
dc.date.issued2002-10
dc.identifier.citationTi, L.K., Cheong, K.-F., Chen, F.-G. (2002-10). Prediction of excessive bleeding after coronary artery bypass graft surgery: The influence of timing and heparinase on thromboelastography. Journal of Cardiothoracic and Vascular Anesthesia 16 (5) : 545-550. ScholarBank@NUS Repository. https://doi.org/10.1053/jcan.2002.126945
dc.identifier.issn10530770
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131169
dc.description.abstractObjective: To compare the ability of thromboelastography, when done at either 10 or 60 minutes after protamine reversal of heparin, to predict excessive bleeding after coronary artery bypass graft (CABG) surgery and to investigate, with the use of heparinase, whether heparin contamination was responsible for the difference, if any. Design: Prospective study. Setting: University hospital, single institution. Participants: Patients undergoing elective CABG surgery (n = 40). Interventions: Blood samples for thromboelastography and routine coagulation tests were collected before induction of anesthesia and at 10 and 60 minutes after protamine reversal of heparin. Blood loss and blood product use were recorded postoperatively. Measurements and Main Results: Of 40 patients undergoing elective CABG surgery, 10 fulfilled the criteria for excessive postoperative bleeding. The sensitivity of thromboelastography to identify patients who bled was better at 60 minutes than at 10 minutes after protamine reversal of heparin (100% v 70%). There was greater specificity (83% v 40% at 10 minutes; 73% v 20% at 60 minutes) and positive predictive value (58% v 28% at 10 minutes; 55% v 29% at 60 minutes) when heparinase was added. At both times, thromboelastography showed only moderate correlation with total blood loss and the use of fresh frozen plasma or platelets or both. Conventional coagulation tests did not predict excessive postoperative bleeding. Conclusion: This study suggests that timing and the use of heparinase influence the predictive ability of thromboelastography, but its usefulness as a sole predictor of post-CABG surgery bleeding is limited. Copyright 2002, Elsevier Science (USA). All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1053/jcan.2002.126945
dc.sourceScopus
dc.subjectCoronary artery bypass graft (CABG) surgery
dc.subjectPostoperative bleeding
dc.subjectThromboelastography
dc.typeArticle
dc.contributor.departmentANAESTHESIA
dc.description.doi10.1053/jcan.2002.126945
dc.description.sourcetitleJournal of Cardiothoracic and Vascular Anesthesia
dc.description.volume16
dc.description.issue5
dc.description.page545-550
dc.description.codenJCVAE
dc.identifier.isiut000178556200003
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