Please use this identifier to cite or link to this item:
|Title:||Nasal-type extranodal natural killer/T-cell lympholmas: A cliniclopathologic and genotypic study of 42 cases in Singapore||Authors:||Ng, S.B.
Natural killer/T-cell lymphoma
P53 and p21
T-cell receptor-gamma gene rearrangement
|Issue Date:||Sep-2004||Citation:||Ng, S.B., Lai, K.W., Murugaya, S., Lee, K.M., Loong, S.L.E., Fook-Chong, S., Tao, M., Sng, I. (2004-09). Nasal-type extranodal natural killer/T-cell lympholmas: A cliniclopathologic and genotypic study of 42 cases in Singapore. Modern Pathology 17 (9) : 1097-1107. ScholarBank@NUS Repository. https://doi.org/10.1038/modpathol.3800157||Abstract:||We studied the clinicopathologic features of 42 cases of nasal-type extranodal natural killer (NK)/T-cell lymphoma in Singapore and compared our findings with other series reported in the Asian and Western populations. A panel of immunohistochemical stains, which included CD2, CD3, CD4, CD8, CD56, T-cell intracellular Antigen-1 and granzyme B, and in situ hybridization for Epstein-Barr virus encoded RNA (EBER) were performed. Polymerase chain reaction for T-cell receptor-gamma gene rearrangement using both gel and capillary electrophoresis were evaluated to determine the proportion of tumors which are of true T-cell lineage. We also studied the functional status of the overexpressed p53 protein in these lymphomas by correlating p53 expression with its downstream target protein, p21. In all, 31 out of 42 cases presented in the upper aerodigestive tract. The other sites of involvement included gastrointestinal tract, skin, soft tissue, testis, liver, spleen, bone marrow and brain. The tumors displayed characteristic morphologic features. In situ hybridization for EBER was detected in 41 out of 42 cases (97.6%). The only significant adverse prognostic factor identified was an International Prognostic Index of two or more. A significantly higher proportion of the tumors (27%), compared to previous studies, demonstrated monoclonal T-cell receptor-gamma gene rearrangement. There was, however, no difference in survival or clinicopathologic features between the true NK-cell tumors and their T-cell counterparts. Overexpression of p53 was present in 40% of the cases, but no significant difference in survival rate was detected in patients with p53 overexpression and there was no association between p53 overexpression with large cell morphology, and advanced stage of disease. These findings suggest that molecular aberrations other than those of the p53 pathway may be operative in the pathogenesis of this malignancy.||Source Title:||Modern Pathology||URI:||http://scholarbank.nus.edu.sg/handle/10635/131102||ISSN:||08933952||DOI:||10.1038/modpathol.3800157|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jul 11, 2019
WEB OF SCIENCETM
checked on Jul 11, 2019
checked on Jul 19, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.