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Title: Human genome - From pieces to patterns
Authors: Sakharkar, M.K.
Kangueane, P.
Perumal, B.S.
Chow, V.T.K. 
Sorscher, E.
Sakharkar, K.R.
Hill, A.
Keywords: Block Length
Exon-Intron Length Patterns
Gene Architecture
Genome Design
Human Genome
Issue Date: 2005
Citation: Sakharkar, M.K., Kangueane, P., Perumal, B.S., Chow, V.T.K., Sorscher, E., Sakharkar, K.R., Hill, A. (2005). Human genome - From pieces to patterns. Frontiers in Bioscience 10 (SUPPL. 2) : 2576-2584. ScholarBank@NUS Repository.
Abstract: A profile of exon-intron lengths in genes shows a normal distribution. This observation suggests that different genes may have portions of their total exon and/or intron lengths in common. In order to explore the common exon-intron structural patterns that may arise due to common lengths across genes, we compared the exon-intron length patterns of annotated human genes. We discovered 1762278 conserved arrangements of exon-intron length across the otherwise unrelated and diverse genomic landscape. The existence of common exon-intron length patterns across unrelated genes suggests for their role of in gene assemblage and human genome design and architecture.
Source Title: Frontiers in Bioscience
ISSN: 10939946
Appears in Collections:Staff Publications

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