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Title: Hantavirus infections in humans and commensal rodents in Singapore
Authors: Wong, T.W.
Chan, Y.C. 
Joo, Y.G.
Lee, H.W.
Lee, P.W.
Yanagihara, R.
Issue Date: Mar-1989
Citation: Wong, T.W., Chan, Y.C., Joo, Y.G., Lee, H.W., Lee, P.W., Yanagihara, R. (1989-03). Hantavirus infections in humans and commensal rodents in Singapore. Transactions of the Royal Society of Tropical Medicine and Hygiene 83 (2) : 248-251. ScholarBank@NUS Repository.
Abstract: To determine the extent of hantavirus infection in Singapore, serological studies using the indirect immunofluorescent antibody (IFA) test were conducted on commensal rodents and on human patients in 4 diagnostic groups. Virus isolation using a Vero E6 cell line was performed on hantaviral antigen-positive rodent lung tissue. Of 142 rodents and 3 insectivores studied, 37 (26%) were seropositive for IFA. Rattus norvegicus was the predominant species captured, with the highest species-specific seropositive rate of 32% (36 of 113). A hantavirus strain, R36, was isolated from one R. norvegicus. Seropositive rates for human patients were: 8% respectively for dengue haemorrhagic fever suspects and for non-A non-B hepatitis patients, 3% for leptospirosis suspects and 2% for acute nephritis patients. 2 patients had marked liver dysfunction but mild renal involvement. This hepatitis-like manifestation appears to be a clinical variant of hantavirus infection. © 1989.
Source Title: Transactions of the Royal Society of Tropical Medicine and Hygiene
ISSN: 00359203
Appears in Collections:Staff Publications

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