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Title: Gastroduodenal dysfunction and bacterial colonisation of the ventilated lung
Authors: Inglis, T.J.J. 
Sherratt, M.J.
Sproat, L.J.
Gibson, J.S.
Hawkey, P.M.
Issue Date: 1993
Citation: Inglis, T.J.J., Sherratt, M.J., Sproat, L.J., Gibson, J.S., Hawkey, P.M. (1993). Gastroduodenal dysfunction and bacterial colonisation of the ventilated lung. Lancet 341 (8850) : 911-913. ScholarBank@NUS Repository.
Abstract: The source of ventilator-associated pneumonia (gastric or oropharyngeal flora) remains controversial. We investigated the source of bacterial colonisation of the ventilated lung in 100 consecutive intensive-care patients. Gram-negative bacilli were isolated from the lower respiratory tract in 19 patients. Bacteria isolated from the stomach contents either previously or at the same time were identical to lower respiratory isolates in 11 patients. No gram-negative oropharyngeal isolate was identical to a lower respiratory tract isolate. Gastric bacterial overgrowth with gram-negative bacilli was associated with the presence of bilirubin in the stomach contents. Detectable bilirubin was also associated with subsequent acquisition of gram-negative bacilli in the lower respiratory tract. Only 5 gastric aspirate specimens with pH
Source Title: Lancet
ISSN: 01406736
Appears in Collections:Staff Publications

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