Please use this identifier to cite or link to this item: https://doi.org/10.1038/sj.onc.1208541
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dc.titlep44/42 MAP kinase-dependent regulation of catalase by autocrine human growth hormone protects human mammary carcinoma cells from oxidative stress-induced apoptosis
dc.contributor.authorZhu, Z.
dc.contributor.authorMukhina, S.
dc.contributor.authorZhu, T.
dc.contributor.authorMertani, H.C.
dc.contributor.authorLee, K.-O.
dc.contributor.authorLobie, P.E.
dc.date.accessioned2016-11-28T10:14:32Z
dc.date.available2016-11-28T10:14:32Z
dc.date.issued2005-05-26
dc.identifier.citationZhu, Z., Mukhina, S., Zhu, T., Mertani, H.C., Lee, K.-O., Lobie, P.E. (2005-05-26). p44/42 MAP kinase-dependent regulation of catalase by autocrine human growth hormone protects human mammary carcinoma cells from oxidative stress-induced apoptosis. Oncogene 24 (23) : 3774-3785. ScholarBank@NUS Repository. https://doi.org/10.1038/sj.onc.1208541
dc.identifier.issn09509232
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/130949
dc.description.abstractPrevious microarray expression analyses have indicated autocrine human growth hormone (hGH) regulation of genes involved in the oxidative stress response. Expression analysis of antioxidant enzymes revealed that autocrine hGH increased both the mRNA and protein levels of catalase, superoxide dismutase 1 (SOD1), glutathione peroxidase and glutamylcysteine synthetase but not that of SOD2. As a consequence, autocrine hGH increased the antioxidant capacity of mammary carcinoma cells and protected against oxidative stress-induced apoptosis. Catalase activity was increased by autocrine production of hGH in mammary carcinoma cells and a catalase inhibitor abrogated protection from oxidative stress afforded by autocrine hGH. Autocrine hGH transcriptionally regulated catalase gene expression in a p44/42 MAP kinase-dependent manner and inhibition of MEK concordantly abrogated the protective effect of autocrine hGH against oxidative stress-induced apoptosis. Given that increased cellular oxidative stress is a key effector mechanism of specific chemotherapeutic agents, we propose that antagonism of autocrine hGH will improve the efficacy of chemotherapeutic regimes utilized for human mammary carcinoma. © 2005 Nature Publishing Group All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/sj.onc.1208541
dc.sourceScopus
dc.subjectAutocrine
dc.subjectCatalase
dc.subjectGrowth hormone
dc.subjectMammary carcinoma
dc.subjectOxidative stress
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.description.doi10.1038/sj.onc.1208541
dc.description.sourcetitleOncogene
dc.description.volume24
dc.description.issue23
dc.description.page3774-3785
dc.description.codenONCNE
dc.identifier.isiut000229346300008
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