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https://scholarbank.nus.edu.sg/handle/10635/130928
Title: | L-asparaginase induced intracranial haemorrhage in acute lymphoblastic leukemia | Authors: | Lim, H.L. Teo, C.P. Wong, K. Kueh, Y.K. |
Keywords: | Acute lymphoblastic leukaemia Hypofibrinogenemia Intracranial haemorrhage L-asparaginase |
Issue Date: | Feb-1998 | Citation: | Lim, H.L., Teo, C.P., Wong, K., Kueh, Y.K. (1998-02). L-asparaginase induced intracranial haemorrhage in acute lymphoblastic leukemia. Singapore Medical Journal 39 (2) : 76-78. ScholarBank@NUS Repository. | Abstract: | A 20-year-old national serviceman with acute lymphoblastic leukaemia, developed a large left parieto-occipital haemorrhage 7 days after completion of induction chemotherapy. Severe hypofibrinogenemia had been noted while he was receiving L-asparaginase. The haemorrhage could not be attributed to thrombocytopenia, disseminated intravascular coagulopathy, arterio-venous malformation, berry aneurysm or leukaemic infiltration because each of these causes was carefully investigated into and excluded. We conclude that the intracranial haemorrhage was likely L-asparaginase induced, an uncommon but recognised complication associated with L-asparaginase therapy. | Source Title: | Singapore Medical Journal | URI: | http://scholarbank.nus.edu.sg/handle/10635/130928 | ISSN: | 00375675 |
Appears in Collections: | Staff Publications |
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