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Title: Osteogenic sarcoma with skeletal muscle metastases
Authors: Peh, W.C.G.
Shek, T.W.H.
Wang, S.-C. 
Wong, J.W.K.
Chien, E.P.
Keywords: Metastases, skeletal muscle
Soft tissue neoplasm
Issue Date: May-1999
Citation: Peh, W.C.G., Shek, T.W.H., Wang, S.-C., Wong, J.W.K., Chien, E.P. (1999-05). Osteogenic sarcoma with skeletal muscle metastases. Skeletal Radiology 28 (5) : 298-304. ScholarBank@NUS Repository.
Abstract: Two cases of osteogenic sarcoma with skeletal muscle metastases are described. A 40-year-old woman presented with progressive swelling of both calves and a soft tissue back lump. She had been diagnosed with mandibular chondroblastic osteogenic sarcoma 6 years earlier. Radiographs showed calcified masses. MRI scans and bone scintigraphy revealed multiple soft tissue masses in both calves. Bone scintigraphy also showed uptake in the back lump, right thigh and left lung base. Biopsy confirmed metastatic chondroblastic osteogenic sarcoma, which initially responded well to chemotherapy. However, the metastatic disease subsequently progressed rapidly and she died 21 months after presentation. The second case concerns a 20-year-old man who presented with a pathologic fracture of the humerus, which was found to be due to osteoblastic osteogenic sarcoma. He developed cerebral metastases 17 months later, followed by metastases at other sites. Calcified masses were subsequently seen on radiographs of the abdomen and chest, CT scans confirmed the presence of densely calcified muscle metastases in the abdominal wall, erector spinae and gluteal muscles. The patient's disease progressed rapidly and he died 30 months after presentation.
Source Title: Skeletal Radiology
ISSN: 03642348
DOI: 10.1007/s002560050521
Appears in Collections:Staff Publications

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