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|Title:||PHARMACOKINETIC AND PHARMACODYNAMIC STUDIES OF THE NOVEL ANTICOAGULANT PEPTIDE VARIEGIN IN RATS AND PIGS||Authors:||NORRAPAT SHIH||Keywords:||pharmacokinetic, pharmacodynamic, anticoagulant, drug development, bioanalytical assays, antithrombotic, percutaneous coronary intervention||Issue Date:||11-Aug-2016||Citation:||NORRAPAT SHIH (2016-08-11). PHARMACOKINETIC AND PHARMACODYNAMIC STUDIES OF THE NOVEL ANTICOAGULANT PEPTIDE VARIEGIN IN RATS AND PIGS. ScholarBank@NUS Repository.||Abstract:||Anticoagulants are used for treatment of thromboembolic disorders. Although effective, current anticoagulants have many limitations, providing the impetus for development of more effective anticoagulants. Previously, we isolated the variegin peptide from salivary glands of the tropical bont tick (Amblyomma variegatum). Variegin was shown to be a high-affinity direct thrombin inhibitor and a potent anticoagulant in vivo. Our plan is to develop variegin into a new anticoagulant. To this end, several animal models will be employed to study the pharmacokinetics and pharmacodynamics of this peptide. For PK studies of variegin in pigs, several bioanalytical assays have been developed for variegin quantitation, namely the LC-MS/MS, thrombin amidolytic and modified thrombin time assays. To study the antithrombotic efficacy and bleeding risk of variegin, the rat carotid artery thrombosis model, rat tail incision model and porcine stent thrombosis model were performed. Variegin has a wider therapeutic window in comparison to both heparin and hirulog.||URI:||http://scholarbank.nus.edu.sg/handle/10635/130770|
|Appears in Collections:||Ph.D Theses (Open)|
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