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Title: Report of an International Workshop: Roadmap for Management of Patients Receiving Oral Therapy for Chronic Hepatitis B
Authors: Keeffe, E.B.
Zeuzem, S.
Koff, R.S.
Dieterich, D.T.
Esteban-Mur, R.
Gane, E.J.
Jacobson, I.M.
Lim, S.G. 
Naoumov, N.
Marcellin, P.
Piratvisuth, T.
Zoulim, F.
Issue Date: Aug-2007
Citation: Keeffe, E.B., Zeuzem, S., Koff, R.S., Dieterich, D.T., Esteban-Mur, R., Gane, E.J., Jacobson, I.M., Lim, S.G., Naoumov, N., Marcellin, P., Piratvisuth, T., Zoulim, F. (2007-08). Report of an International Workshop: Roadmap for Management of Patients Receiving Oral Therapy for Chronic Hepatitis B. Clinical Gastroenterology and Hepatology 5 (8) : 890-897. ScholarBank@NUS Repository.
Abstract: An international group of experienced hepatologists and virologists conducted a single-day workshop to review the management of patients with chronic hepatitis B receiving treatment with oral nucleosides or nucleotides. Guidelines regarding on-treatment management and available published data on the importance of serum hepatitis B virus (HBV) DNA as a marker of outcomes were reviewed. On-treatment monitoring strategies to define early virologic responses that might be predictive of better outcomes and a reduced risk of viral resistance were proposed for further study. This treatment plan, labeled the roadmap concept, recommends monitoring of serum HBV DNA levels to identify outcomes of therapy. Primary treatment failure was defined as a reduction of serum HBV DNA levels by less than 1 log10 IU/mL from baseline at week 12. Measurement of the HBV DNA level at week 24 was considered essential to characterize virologic responses as complete, partial, or inadequate. Complete virologic response was defined as negative HBV DNA by a sensitive assay (
Source Title: Clinical Gastroenterology and Hepatology
ISSN: 15423565
DOI: 10.1016/j.cgh.2007.05.004
Appears in Collections:Staff Publications

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