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Title: Identification of polymorphisms in the nuclear receptors (PXR, CAR and HNF4X) genes in the local population
Keywords: Polymorphism nuclear receptors PXR CAR HNF4X
Issue Date: 5-Feb-2008
Citation: HOR SOK YING (2008-02-05). Identification of polymorphisms in the nuclear receptors (PXR, CAR and HNF4X) genes in the local population. ScholarBank@NUS Repository.
Abstract: The nuclear receptor (NR) superfamily is a large class of pharmacologically important receptors that play vital roles in the defence mechanisms in the human body. It is responsible for protecting the body from a diverse array of harmful endogenous and exogenous toxins by modulating the expression of the genes involved in drug metabolism and disposition. The detoxifying and elimination of these toxins is mainly mediated by cytochrome P450 (CYP) enzymes, along with phase I and phase II drug metabolising enzymes, as well as drug transporters. Three closely related nuclear receptors, namely the pregnane X receptor (PXR), constitutive androstane receptor (CAR) and hepatocyte nuclear factor 4-alpha (HNF4x) have recently been identified as the master transcriptional regulators of CYPs expression. It is hypothesized that genetic variation in these nuclear receptors may contribute to human inter-individual variation in drug metabolism and also drug-drug interactions.
Appears in Collections:Master's Theses (Open)

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