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Title: Unravelling the mystery in a case of persistent ACTH-independent Cushing's syndrome
Authors: Ling, C.L.
Tan, L.H.C. 
Rajasoorya, C.
Keywords: Adrenocortical hyperfunction
Cushing's syndrome
Nodular adrenocortical disease
Issue Date: Dec-2006
Citation: Ling, C.L., Tan, L.H.C., Rajasoorya, C. (2006-12). Unravelling the mystery in a case of persistent ACTH-independent Cushing's syndrome. Annals of the Academy of Medicine Singapore 35 (12) : 892-896. ScholarBank@NUS Repository.
Abstract: Introduction: We present a rare variety of adrenocorticotrophic hormone (ACTH)-independent Cushing's syndrome known as primary pigmented nodular adrenocortical disease (PPNAD). Clinical Picture: The patient initially underwent unilateral adrenalectomy for what was thought to be a left adrenal adenoma. Outcome: Partial resolution of symptoms and demonstrable persistent hypercortisolism after surgery prompted further evaluation with findings leading to the diagnosis of Carney complex. A review of the adrenal histology was consistent with PPNAD. Conclusion: This entity of PPNAD, which has rarely been reported in Asians, forms part of the Carney complex. The diagnosis may not be simple and straightforward, as illustrated in this patient.
Source Title: Annals of the Academy of Medicine Singapore
ISSN: 03044602
Appears in Collections:Staff Publications

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