Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biocel.2005.03.006
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dc.titleThe osteoblast-heparan sulfate axis: Control of the bone cell lineage
dc.contributor.authorCool, S.M.
dc.contributor.authorNurcombe, V.
dc.date.accessioned2016-11-17T08:38:59Z
dc.date.available2016-11-17T08:38:59Z
dc.date.issued2005-09
dc.identifier.citationCool, S.M., Nurcombe, V. (2005-09). The osteoblast-heparan sulfate axis: Control of the bone cell lineage. International Journal of Biochemistry and Cell Biology 37 (9) : 1739-1745. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biocel.2005.03.006
dc.identifier.issn13572725
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/130592
dc.description.abstractDuring osteogenesis, mesenchymal stem cells are recruited to the osteoblast lineage and progressively differentiate into osteoblasts that produce a mineralised extracellular matrix. Although most of the organic component of this matrix is comprised of collagen, growing evidence suggests the most bioactive element of a developing matrix is its heparan sulfate glycosaminoglycan complement. This species of linear, unbranched sugars contain protein-binding domains that regulate the flow of an astonishing number of mitogenic influences that coordinate mesenchymal stem cell commitment and growth, and ultimately, osteoblast phenotype. Among the heparan sulfate-binding factors known to be important to this process are sonic hedgehog, the fibroblast growth factors and their receptors, members of the transforming growth factor superfamily, as well as the collagens, laminins and fibronectins. How these sugars change during development to bring together the right combination of mitogenic/differentiative influences to trigger the successive phases of osteogenesis is currently the focus of intense research. © 2005 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.biocel.2005.03.006
dc.sourceScopus
dc.subjectExtracellular matrix
dc.subjectGrowth factors
dc.subjectOsteogenesis
dc.subjectProteoglycans
dc.subjectStem cell niche
dc.typeArticle
dc.contributor.departmentORTHOPAEDIC SURGERY
dc.description.doi10.1016/j.biocel.2005.03.006
dc.description.sourcetitleInternational Journal of Biochemistry and Cell Biology
dc.description.volume37
dc.description.issue9
dc.description.page1739-1745
dc.description.codenIJBBF
dc.identifier.isiut000231103500001
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