Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M600224200
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dc.titleαCP1 mediates stabilization of hTERT mRNA by autocrine human growth hormone
dc.contributor.authorEmerald, B.S.
dc.contributor.authorChen, Y.
dc.contributor.authorZhu, T.
dc.contributor.authorZhu, Z.
dc.contributor.authorLee, K.-O.
dc.contributor.authorGluckman, P.D.
dc.contributor.authorLobie, P.E.
dc.date.accessioned2016-11-17T08:38:48Z
dc.date.available2016-11-17T08:38:48Z
dc.date.issued2007-01-05
dc.identifier.citationEmerald, B.S., Chen, Y., Zhu, T., Zhu, Z., Lee, K.-O., Gluckman, P.D., Lobie, P.E. (2007-01-05). αCP1 mediates stabilization of hTERT mRNA by autocrine human growth hormone. Journal of Biological Chemistry 282 (1) : 680-690. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M600224200
dc.identifier.issn00219258
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/130577
dc.description.abstractWe herein demonstrate that autocrine human growth hormone production in human mammary carcinoma cells results in increased telomerase activity as a result of specific up-regulation of telomerase catalytic subunit (human telomerase reverse transcriptase (hTERT)) mRNA and protein. This increase in hTERT gene expression is not due to increased transcriptional activation of the hTERT promoter but is the result of increased stability of hTERT mRNA exerted by CU-rich cis-regulatory sequences present in the 3′-untranslated region of TERT mRNA. Autocrine human growth hormone up-regulates two poly(C)-binding proteins, αCP1 and αCP2, which bind to these cis-regulatory elements and stabilize hTERT mRNA. We have therefore demonstrated that post-transcriptional modulation of the level of hTERT mRNA is one mechanism for regulation of cellular telomerase activity. © 2007 by The American Society for Biochemistry and Molecular Biology, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1074/jbc.M600224200
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.description.doi10.1074/jbc.M600224200
dc.description.sourcetitleJournal of Biological Chemistry
dc.description.volume282
dc.description.issue1
dc.description.page680-690
dc.description.codenJBCHA
dc.identifier.isiut000243166500073
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