Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jcv.2006.11.002
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dc.titleSymptoms and risk factors of ocular complications following dengue infection
dc.contributor.authorSeet, R.C.S.
dc.contributor.authorQuek, A.M.L.
dc.contributor.authorLim, E.C.H.
dc.date.accessioned2016-11-17T08:38:45Z
dc.date.available2016-11-17T08:38:45Z
dc.date.issued2007-02
dc.identifier.citationSeet, R.C.S., Quek, A.M.L., Lim, E.C.H. (2007-02). Symptoms and risk factors of ocular complications following dengue infection. Journal of Clinical Virology 38 (2) : 101-105. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jcv.2006.11.002
dc.identifier.issn13866532
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/130572
dc.description.abstractBackground: Dengue infection can result in severe ocular complications. We prospectively studied the range of ocular symptoms in a cohort of patients with dengue infection. Methods: We included adult patients with serologically confirmed dengue infection who received clinical care at the National University Hospital, Singapore. They were assessed for demographic characteristics, ocular symptoms, laboratory parameters and dengue severity. Patients with two or more ocular symptoms were referred to an ophthalmologist and underwent full ophthalmologic examination that included visual acuity, slit-lamp examination and indirect fundoscopic examination. Descriptive and logistic regression analyses were performed and statistical significance was set at p < 0.05. Results: One hundred and fifty-six patients, aged (S.D.) 33.94 (12.7) years, consisting of 89 (57.1%) males and 67 (42.9%) females, participated in this study. They reported ocular symptoms, such as eye strain (30%), retro-ocular pain (20%), blurring of vision (10%), double vision (3%), foreign body sensation (3%), eye flashes (2%) and floaters (1%). Multivariate analysis identified white cell count (odds ratio, OR 0.531; 95% CI 0.292, 0.963) and serum albumin (OR 0.758; 95% confidence intervals, CI 0.618, 0.928) as significant predictors of clinically significant ocular symptoms. The triad of symptoms (eye flashes, floaters and blurring of vision) was highly predictive for the development of retinal hemorrhages (positive predictive value 100%). Conclusions: Dengue virus results in a spectrum of ocular manifestations, ranging from non-specific symptoms to severe retinal hemorrhages. Further studies are needed to validate the triad of ocular symptoms as a screening tool for severe ocular complications following dengue infection. © 2006 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.jcv.2006.11.002
dc.sourceScopus
dc.subjectDengue
dc.subjectHypoalbuminemia
dc.subjectLeukopenia
dc.subjectOcular complications
dc.subjectScreening tool
dc.subjectSymptoms
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.description.doi10.1016/j.jcv.2006.11.002
dc.description.sourcetitleJournal of Clinical Virology
dc.description.volume38
dc.description.issue2
dc.description.page101-105
dc.description.codenJCVIF
dc.identifier.isiut000244400200003
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