Please use this identifier to cite or link to this item:
|Title:||The association between circulating white blood cell count, triglyceride level and cardiovascular and all-cause mortality: Population-based cohort study||Authors:||Shankar, A.
|Keywords:||Blue Mountains Eye Study
|Issue Date:||May-2007||Citation:||Shankar, A., Mitchell, P., Rochtchina, E., Wang, J.J. (2007-05). The association between circulating white blood cell count, triglyceride level and cardiovascular and all-cause mortality: Population-based cohort study. Atherosclerosis 192 (1) : 177-183. ScholarBank@NUS Repository. https://doi.org/10.1016/j.atherosclerosis.2006.04.029||Abstract:||Objectives: To examine the individual and combined relationship between elevated white blood cell count (WBC), triglyceride level and cardiovascular and all-cause mortality among older Australians. Design: Prospective population-based cohort study. Setting: Community in Blue Mountains region, Australia. Participants: 2904 individuals, aged 49-84 years, free of cardiovascular disease and cancer at the baseline examination. Main outcome measures: Cardiovascular (n = 242) and all-cause mortality (n = 575). Results: Elevated WBC count and triglyceride level were found to be associated with cardiovascular and all-cause mortality, independent of several important confounders. Multivariable relative risk [RR] (95% confidence interval [CI]) comparing fourth (6.8 × 109 cells/L and above) versus first quartile (4.8 × 109 cells/L and below) of WBC count was 2.01 (1.40-2.90) for cardiovascular mortality and 1.68 (1.35-2.09) for all-cause mortality. Multivariable RR (95% CI) comparing fourth (1.98 mmol/L and above) versus first quartile (0.95 mmol/L and below) of triglyceride level was 1.58 (1.08-2.30) for cardiovascular mortality and 1.40 (1.11-1.77) for all-cause mortality. Furthermore, a combined exposure to the fourth quartiles of both WBC count and triglyceride level was found to be related to more than three-fold risk of cardiovascular mortality (RR [95% CI]: 3.15 [2.17-4.57], p-interaction = 0.01), independent of traditional risk factors. Conclusions: Elevated WBC count and triglyceride level were associated with cardiovascular and all-cause mortality among older Australians. These data provide new epidemiological evidence regarding cardiovascular risk stratification using simple, inexpensive, and routinely available measures, suggesting that a combined exposure to both high WBC count and triglyceride level is related to more than three-fold risk of cardiovascular mortality, independent of traditional risk factors. © 2006 Elsevier Ireland Ltd. All rights reserved.||Source Title:||Atherosclerosis||URI:||http://scholarbank.nus.edu.sg/handle/10635/130563||ISSN:||00219150||DOI:||10.1016/j.atherosclerosis.2006.04.029|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Apr 22, 2019
WEB OF SCIENCETM
checked on Apr 22, 2019
checked on Apr 19, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.