Please use this identifier to cite or link to this item:
|Title:||The significance of the Wnt pathway in the pathology of human cancers||Authors:||Karim, R.Z.
Frizzled membrane receptor
|Issue Date:||Apr-2004||Citation:||Karim, R.Z., Tse, G.M.K., Putti, T.C., Scolyer, R.A., Lee, C.S. (2004-04). The significance of the Wnt pathway in the pathology of human cancers. Pathology 36 (2) : 120-128. ScholarBank@NUS Repository. https://doi.org/10.1080/00313020410001671957||Abstract:||The wingless-type (Wnt) signalling transduction pathway is essentially a network of a number of separate but interacting pathways. Specific Wnt ligands bind to their target 'frizzled' membrane receptor and interfere with the multi-protein destruction complex, resulting in downstream activation of gene transcription by β-catenin. Simplistically, the multi-protein destruction complex involves Axin and APC serving as scaffolds binding both β-catenin and GSK3, to facilitate phosphorylation of β-catenin by GSK-3β. Phosphorylated β-catenin is degraded in proteasomes by the ubiquination machinery. Unphosphorylated β-catenin accumulates and associates with nuclear transcription factors leading to the eventual transcription and expression of target genes such as c-myc, c-jun, Fra and cyclin D1. There are several regulatory mechanisms for the down-regulation of the Wnt/ β-catenin signal, perhaps reflecting the pivotal nature of the pathway and the detrimental consequences of inappropriate activation. There has been intense investigation into the role of Wnt genes in human cancer. Although no documentation is made of any mutation or amplification of genes encoding Wnt ligands or receptors linked to human cancer to date, several components of the Wnt pathway have been implicated in carcinogenesis, especially APC and β-catenin.||Source Title:||Pathology||URI:||http://scholarbank.nus.edu.sg/handle/10635/130524||ISSN:||00313025||DOI:||10.1080/00313020410001671957|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jul 7, 2020
WEB OF SCIENCETM
checked on Jul 7, 2020
checked on Jul 11, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.