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Title: Serum lipoprotein(a) profiles in a Singaporean poplulation
Authors: Wong, M.-S.
Chew, W.L.S.
Aw, T.-C. 
Keywords: Cholesterol
Coronary heart disease
Ethnic variation
Issue Date: 1999
Citation: Wong, M.-S., Chew, W.L.S., Aw, T.-C. (1999). Serum lipoprotein(a) profiles in a Singaporean poplulation. Pathology 31 (3) : 225-229. ScholarBank@NUS Repository.
Abstract: Lipoprotein(a) [Lp(a)] is formed when apolipoprotein(a) is linked to low density lipoprotein (LDL)-cholesterol via a single disulfide bond. It is an independent risk factor for myocardial infarction and raised concentrations are associated with an increased risk of developing coronary artery disease. Singapore has a multi-racial population of 77% Chinese, 14% Malays and 7% Indians. Studies have shown that the Indians have significantly higher standardised mortality ratios (SMR) compared to the Chinese and the Malays. We measured serum Lp(a) concentrations in 803 healthy individuals recruited from the Multiphasic Health Screening Programme, using the Macra Lp(a) sandwich enzyme immunoassay kit. Lp(a) concentrations were skewed in all three groups. Our population mean was 9.0 mg/dl, with 50th, 75th and 95th percentile values of 10.2, 19.8 and 43.1 mg/dl, respectively, which are lower than values reported from Caucasian populations (15.0, 29.0 and 60.0 mg/dl, respectively). Males had lower Lp(a) concentrations than females (P < 0.05). The Indian group had significantly higher concentrations (median 12.3 mg/dl) compared to their Chinese (median 9.6 mg/dl) and Malay (median 8.4 mg/dl) counterparts (P < 0.05). This could partly account for the higher SMR seen in the Indian population in Singapore. As serum Lp(a) concentrations are method - and population-dependent, we recommend that laboratories determine their own reference ranges by their method to avoid misclassification of the coronary heart disease (CHD) risk of patients.
Source Title: Pathology
ISSN: 00313025
DOI: 10.1080/003130299105034
Appears in Collections:Staff Publications

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