Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neurobiolaging.2007.10.013
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dc.titleSORL1 haplotypes modulate risk of Alzheimer's disease in Chinese
dc.contributor.authorTan, E.K.
dc.contributor.authorLee, J.
dc.contributor.authorChen, C.P.
dc.contributor.authorTeo, Y.Y.
dc.contributor.authorZhao, Y.
dc.contributor.authorLee, W.L.
dc.date.accessioned2016-11-11T08:00:09Z
dc.date.available2016-11-11T08:00:09Z
dc.date.issued2009-07
dc.identifier.citationTan, E.K., Lee, J., Chen, C.P., Teo, Y.Y., Zhao, Y., Lee, W.L. (2009-07). SORL1 haplotypes modulate risk of Alzheimer's disease in Chinese. Neurobiology of Aging 30 (7) : 1048-1051. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neurobiolaging.2007.10.013
dc.identifier.issn01974580
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/130030
dc.description.abstractGenetic variants of the neuronal sortilin-related receptor (SORL1) have been demonstrated to modulate the risk of Alzheimer's disease (AD) in different American and European populations [Rogaeva, E., Meng, Y., Lee, J.H., Gu, Y., Kawarai, T., Zou, F., Katayama, T., Baldwin, C.T., Cheng, R., Hasegawa, H., Chen, F., Shibata, N., Lunetta, K.L., Pardossi-Piquard, R., Bohm, C., Wakutani, Y., Cupples, L.A., Cuenco, K.T., Green, R.C., Pinessi, L., Rainero, I., Sorbi, S., Bruni, A., Duara, R., Friedland, R.P., Inzelberg, R., Hampe, W., Bujo, H., Song, Y.Q., Andersen, O.M., Willnow, T.E., Graff-Radford, N., Petersen, R.C., Dickson, D., Der, S.D., Fraser, P.E., Schmitt-Ulms, G., Younkin, S., Mayeux, R., Farrer, L.A., St George-Hyslop, P., 2007. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat. Genet. 39 (2), 168-177]. We conducted haloptype analysis involving two genetic clusters of SORL1 in AD and controls among Han Chinese. rs3824968 (SNP 23) was associated with an increased risk of AD, and there was a trend towards association for rs1699102 (SNP 22) and rs2282649 (SNP 24). More robust associations were found for three-loci haplotypes. In particular, the GCA haplotype at SNPs 19-22-23 was associated with an increased risk (odds ratio 1.4), and CTC haplotype at SNPs 19-22-23 and TCT at SNPs 22-23-24 a decreased risk (odds ratio 0.67) of AD. The complete absence of some at-risk North European haplotypes in our Chinese study subjects was likely due to different ancestral origins, with allelic heterogeneity among races. However, our study suggests that certain SORL1 haplotypes at SNPs 19-24 modulated risk of AD in our Chinese population. © 2007 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.neurobiolaging.2007.10.013
dc.sourceScopus
dc.subjectAlzheimer's disease
dc.subjectChinese
dc.subjectHaplotype
dc.subjectSORL1
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.contributor.departmentPHARMACOLOGY
dc.contributor.departmentPAEDIATRICS
dc.description.doi10.1016/j.neurobiolaging.2007.10.013
dc.description.sourcetitleNeurobiology of Aging
dc.description.volume30
dc.description.issue7
dc.description.page1048-1051
dc.description.codenNEAGD
dc.identifier.isiut000266619800004
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