Please use this identifier to cite or link to this item:
|Title:||SORL1 haplotypes modulate risk of Alzheimer's disease in Chinese||Authors:||Tan, E.K.
|Issue Date:||Jul-2009||Citation:||Tan, E.K., Lee, J., Chen, C.P., Teo, Y.Y., Zhao, Y., Lee, W.L. (2009-07). SORL1 haplotypes modulate risk of Alzheimer's disease in Chinese. Neurobiology of Aging 30 (7) : 1048-1051. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neurobiolaging.2007.10.013||Abstract:||Genetic variants of the neuronal sortilin-related receptor (SORL1) have been demonstrated to modulate the risk of Alzheimer's disease (AD) in different American and European populations [Rogaeva, E., Meng, Y., Lee, J.H., Gu, Y., Kawarai, T., Zou, F., Katayama, T., Baldwin, C.T., Cheng, R., Hasegawa, H., Chen, F., Shibata, N., Lunetta, K.L., Pardossi-Piquard, R., Bohm, C., Wakutani, Y., Cupples, L.A., Cuenco, K.T., Green, R.C., Pinessi, L., Rainero, I., Sorbi, S., Bruni, A., Duara, R., Friedland, R.P., Inzelberg, R., Hampe, W., Bujo, H., Song, Y.Q., Andersen, O.M., Willnow, T.E., Graff-Radford, N., Petersen, R.C., Dickson, D., Der, S.D., Fraser, P.E., Schmitt-Ulms, G., Younkin, S., Mayeux, R., Farrer, L.A., St George-Hyslop, P., 2007. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat. Genet. 39 (2), 168-177]. We conducted haloptype analysis involving two genetic clusters of SORL1 in AD and controls among Han Chinese. rs3824968 (SNP 23) was associated with an increased risk of AD, and there was a trend towards association for rs1699102 (SNP 22) and rs2282649 (SNP 24). More robust associations were found for three-loci haplotypes. In particular, the GCA haplotype at SNPs 19-22-23 was associated with an increased risk (odds ratio 1.4), and CTC haplotype at SNPs 19-22-23 and TCT at SNPs 22-23-24 a decreased risk (odds ratio 0.67) of AD. The complete absence of some at-risk North European haplotypes in our Chinese study subjects was likely due to different ancestral origins, with allelic heterogeneity among races. However, our study suggests that certain SORL1 haplotypes at SNPs 19-24 modulated risk of AD in our Chinese population. © 2007 Elsevier Inc. All rights reserved.||Source Title:||Neurobiology of Aging||URI:||http://scholarbank.nus.edu.sg/handle/10635/130030||ISSN:||01974580||DOI:||10.1016/j.neurobiolaging.2007.10.013|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 15, 2020
WEB OF SCIENCETM
checked on Jan 8, 2020
checked on Jan 17, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.