Please use this identifier to cite or link to this item: https://doi.org/10.1080/15265160902788645
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dc.titleUnintended changes in cognition, mood, and behavior arising from cell-based interventions for neurological conditions: Ethical challenges
dc.contributor.authorDuggan, P.S.
dc.contributor.authorSiegel, A.W.
dc.contributor.authorBlass, D.M.
dc.contributor.authorBok, H.
dc.contributor.authorCoyle, J.T.
dc.contributor.authorFaden, R.
dc.contributor.authorFinkel, J.
dc.contributor.authorGearhart, J.D.
dc.contributor.authorGreely, H.T.
dc.contributor.authorHillis, A.
dc.contributor.authorHoke, A.
dc.contributor.authorJohnson, R.
dc.contributor.authorJohnston, M.
dc.contributor.authorKahn, J.
dc.contributor.authorKerr, D.
dc.contributor.authorKing, P.
dc.contributor.authorKurtzberg, J.
dc.contributor.authorLiao, S.M.
dc.contributor.authorMcDonald, J.W.
dc.contributor.authorMcKhann, G.
dc.contributor.authorNelson, K.B.
dc.contributor.authorRao, M.
dc.contributor.authorRegenberg, A.
dc.contributor.authorSmith, K.
dc.contributor.authorSolter, D.
dc.contributor.authorSong, H.
dc.contributor.authorSugarman, J.
dc.contributor.authorTraystman, R.J.
dc.contributor.authorVescovi, A.
dc.contributor.authorYanofski, J.
dc.contributor.authorYoung, W.
dc.contributor.authorMathews, D.J.H.
dc.date.accessioned2016-11-11T08:00:05Z
dc.date.available2016-11-11T08:00:05Z
dc.date.issued2009-05
dc.identifier.citationDuggan, P.S., Siegel, A.W., Blass, D.M., Bok, H., Coyle, J.T., Faden, R., Finkel, J., Gearhart, J.D., Greely, H.T., Hillis, A., Hoke, A., Johnson, R., Johnston, M., Kahn, J., Kerr, D., King, P., Kurtzberg, J., Liao, S.M., McDonald, J.W., McKhann, G., Nelson, K.B., Rao, M., Regenberg, A., Smith, K., Solter, D., Song, H., Sugarman, J., Traystman, R.J., Vescovi, A., Yanofski, J., Young, W., Mathews, D.J.H. (2009-05). Unintended changes in cognition, mood, and behavior arising from cell-based interventions for neurological conditions: Ethical challenges. American Journal of Bioethics 9 (5) : 31-36. ScholarBank@NUS Repository. https://doi.org/10.1080/15265160902788645
dc.identifier.issn15265161
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/130025
dc.description.abstractThe prospect of using cell-based interventions (CBIs) to treat neurological conditions raises several important ethical and policy questions. In this target article, we focus on issues related to the unique constellation of traits that characterize CBIs targeted at the central nervous system. In particular, there is at least a theoretical prospect that these cells will alter the recipients' cognition, mood, and behavior-brain functions that are central to our concept of the self. The potential for such changes, although perhaps remote, is cause for concern and careful ethical analysis. Both to enable better informed consent in the future and as an end in itself, we argue that early human trials of CBIs for neurological conditions must monitor subjects for changes in cognition, mood, and behavior; further, we recommend concrete steps for that monitoring. Such steps will help better characterize the potential risks and benefits of CBIs as they are tested and potentially used for treatment. © Taylor & Francis Group, LLC.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1080/15265160902788645
dc.sourceScopus
dc.subjectCNS
dc.subjectPersonal identity
dc.subjectRisks
dc.subjectStem cells
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1080/15265160902788645
dc.description.sourcetitleAmerican Journal of Bioethics
dc.description.volume9
dc.description.issue5
dc.description.page31-36
dc.identifier.isiut000266144900012
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