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Title: CD40L-expressing CD8 T cells prime CD8α+ DC for IL-12p70 production
Authors: Wong, K.L.
Lew, F.C.
MacAry, P.A. 
Kemeny, D.M. 
Keywords: CD8 T cells
Dendritic cells
Issue Date: Aug-2008
Citation: Wong, K.L., Lew, F.C., MacAry, P.A., Kemeny, D.M. (2008-08). CD40L-expressing CD8 T cells prime CD8α+ DC for IL-12p70 production. European Journal of Immunology 38 (8) : 2251-2262. ScholarBank@NUS Repository.
Abstract: CD8α+ DC are implicated as the principle DC subset for cross-presentation and cross-priming of cytotoxic CD8 T cell responses. In this study, we demonstrate another unique facet of the CD8α + DC and CD8 T cell relationship, by showing that CD8 T cells reciprocally activate CD8α+ DC, but not CD8α- DC, for IL-12p70 production, the key Th1-promoting cytokine. This effect was observed during an antigen-specific interaction between DC and activated CD8 T cells, along with secondary TLR stimulation of DC by LPS. Activated CD8 T cells use a combination of IFN-γ and CD40L, which is rapidly up-regulated post-stimulation, to prime DC for IL-12p70 production during an antigen-specific response. Our results suggest that the interaction between CD8α+ DC and antigen-primed CD8 T cells may form an important component of Th1-mediated immunity through the induction of IL-12p70. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: European Journal of Immunology
ISSN: 00142980
DOI: 10.1002/eji.200838199
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