Please use this identifier to cite or link to this item:
|Title:||CD40L-expressing CD8 T cells prime CD8α+ DC for IL-12p70 production||Authors:||Wong, K.L.
|Keywords:||CD8 T cells
|Issue Date:||Aug-2008||Citation:||Wong, K.L., Lew, F.C., MacAry, P.A., Kemeny, D.M. (2008-08). CD40L-expressing CD8 T cells prime CD8α+ DC for IL-12p70 production. European Journal of Immunology 38 (8) : 2251-2262. ScholarBank@NUS Repository. https://doi.org/10.1002/eji.200838199||Abstract:||CD8α+ DC are implicated as the principle DC subset for cross-presentation and cross-priming of cytotoxic CD8 T cell responses. In this study, we demonstrate another unique facet of the CD8α + DC and CD8 T cell relationship, by showing that CD8 T cells reciprocally activate CD8α+ DC, but not CD8α- DC, for IL-12p70 production, the key Th1-promoting cytokine. This effect was observed during an antigen-specific interaction between DC and activated CD8 T cells, along with secondary TLR stimulation of DC by LPS. Activated CD8 T cells use a combination of IFN-γ and CD40L, which is rapidly up-regulated post-stimulation, to prime DC for IL-12p70 production during an antigen-specific response. Our results suggest that the interaction between CD8α+ DC and antigen-primed CD8 T cells may form an important component of Th1-mediated immunity through the induction of IL-12p70. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.||Source Title:||European Journal of Immunology||URI:||http://scholarbank.nus.edu.sg/handle/10635/129780||ISSN:||00142980||DOI:||10.1002/eji.200838199|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 16, 2019
WEB OF SCIENCETM
checked on Oct 8, 2019
checked on Oct 11, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.