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Title: A cell culture (Vero)-derived H5N1 whole-virus vaccine induces cross-reactive memory responses
Authors: Ehrlich, H.J.
Müller, M.
Fritsch, S.
Zeitlinger, M.
Berezuk, G.
Löw-Baselli, A.
Van Der Velden, M.V.W.
Pöllabauer, E.M.
Maritsch, F.
Pavlova, B.G.
Tambyah, P.A. 
Oh, H.M.L.
Montomoli, E.
Kistner, O.
Noel Barrett, P.
Issue Date: 1-Oct-2009
Citation: Ehrlich, H.J., Müller, M., Fritsch, S., Zeitlinger, M., Berezuk, G., Löw-Baselli, A., Van Der Velden, M.V.W., Pöllabauer, E.M., Maritsch, F., Pavlova, B.G., Tambyah, P.A., Oh, H.M.L., Montomoli, E., Kistner, O., Noel Barrett, P. (2009-10-01). A cell culture (Vero)-derived H5N1 whole-virus vaccine induces cross-reactive memory responses. Journal of Infectious Diseases 200 (7) : 1113-1118. ScholarBank@NUS Repository.
Abstract: Novel strategies are required to provide rapid vaccine coverage in the event of an influenza pandemic. A phase I/II dose finding/ formulation study was performed with a whole-virus H5N1 clade 1 A/Vietnam vaccine (2-dose priming regimen) to evaluate safety and immunogenicity. Seventy-seven of 141 subjects in this study received a booster (12-17 months after priming) with a 7.5-μg dose of a clade 2.1 A/Indonesia vaccine. The prime-boost regimen resulted in antibody responses against clade 1, 2.1, 2.2, and 2.3 viruses that were significantly higher than those after the priming regimen. These findings demonstrate that a prime-boost regimen may alleviate vaccine supply constraints in a pandemic. © 2009 by the Infectious Diseases Society of America. All rights reserved.
Source Title: Journal of Infectious Diseases
ISSN: 00221899
DOI: 10.1086/605608
Appears in Collections:Staff Publications

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