Please use this identifier to cite or link to this item:
Title: Elevated Thyroid Peroxidase Antibodies with Encephalopathy in MELAS Syndrome
Authors: Chan, D.W.S.
Lim, C.C.T. 
Tay, S.K.H. 
Choong, C.-T. 
Phuah, H.K.
Issue Date: Jun-2007
Citation: Chan, D.W.S., Lim, C.C.T., Tay, S.K.H., Choong, C.-T., Phuah, H.K. (2007-06). Elevated Thyroid Peroxidase Antibodies with Encephalopathy in MELAS Syndrome. Pediatric Neurology 36 (6) : 414-417. ScholarBank@NUS Repository.
Abstract: Both the syndrome of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS syndrome) and Hashimoto's encephalopathy can present with nonspecific encephalopathy. Hashimoto's encephalopathy is an association of steroid-responsive encephalopathy with elevated thyroid peroxidase antibodies. Steroid-responsive encephalopathy, however, is not characteristic of the MELAS syndrome, which typically presents with stroke-like episodes and lactic acidosis in cerebrospinal fluid and blood. Here, a patient is described with goiter, recurrent encephalopathy and elevated thyroid peroxidase antibodies who apparently responded to steroid therapy; however, magnetic resonance imaging was atypical for Hashimoto's encephalopathy, and she was diagnosed with MELAS syndrome. This syndrome can present with apparent steroid-responsive encephalopathy and elevated thyroid peroxidase antibodies, mimicking Hashimoto's encephalopathy, and should be suspected if lactic acidosis is present and typical features are detected on magnetic resonance imaging. © 2007 Elsevier Inc. All rights reserved.
Source Title: Pediatric Neurology
ISSN: 08878994
DOI: 10.1016/j.pediatrneurol.2007.02.005
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Jul 6, 2022


checked on Jul 6, 2022

Page view(s)

checked on Jun 23, 2022

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.