Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.pediatrneurol.2007.02.005
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dc.titleElevated Thyroid Peroxidase Antibodies with Encephalopathy in MELAS Syndrome
dc.contributor.authorChan, D.W.S.
dc.contributor.authorLim, C.C.T.
dc.contributor.authorTay, S.K.H.
dc.contributor.authorChoong, C.-T.
dc.contributor.authorPhuah, H.K.
dc.date.accessioned2016-11-08T08:25:59Z
dc.date.available2016-11-08T08:25:59Z
dc.date.issued2007-06
dc.identifier.citationChan, D.W.S., Lim, C.C.T., Tay, S.K.H., Choong, C.-T., Phuah, H.K. (2007-06). Elevated Thyroid Peroxidase Antibodies with Encephalopathy in MELAS Syndrome. Pediatric Neurology 36 (6) : 414-417. ScholarBank@NUS Repository. https://doi.org/10.1016/j.pediatrneurol.2007.02.005
dc.identifier.issn08878994
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/129743
dc.description.abstractBoth the syndrome of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS syndrome) and Hashimoto's encephalopathy can present with nonspecific encephalopathy. Hashimoto's encephalopathy is an association of steroid-responsive encephalopathy with elevated thyroid peroxidase antibodies. Steroid-responsive encephalopathy, however, is not characteristic of the MELAS syndrome, which typically presents with stroke-like episodes and lactic acidosis in cerebrospinal fluid and blood. Here, a patient is described with goiter, recurrent encephalopathy and elevated thyroid peroxidase antibodies who apparently responded to steroid therapy; however, magnetic resonance imaging was atypical for Hashimoto's encephalopathy, and she was diagnosed with MELAS syndrome. This syndrome can present with apparent steroid-responsive encephalopathy and elevated thyroid peroxidase antibodies, mimicking Hashimoto's encephalopathy, and should be suspected if lactic acidosis is present and typical features are detected on magnetic resonance imaging. © 2007 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.pediatrneurol.2007.02.005
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDIAGNOSTIC RADIOLOGY
dc.contributor.departmentPAEDIATRICS
dc.description.doi10.1016/j.pediatrneurol.2007.02.005
dc.description.sourcetitlePediatric Neurology
dc.description.volume36
dc.description.issue6
dc.description.page414-417
dc.description.codenPNEUE
dc.identifier.isiut000247544300012
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