Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tcb.2007.09.007
DC FieldValue
dc.titleCollective guidance of collective cell migration
dc.contributor.authorRørth, P.
dc.date.accessioned2016-11-08T08:25:06Z
dc.date.available2016-11-08T08:25:06Z
dc.date.issued2007-12
dc.identifier.citationRørth, P. (2007-12). Collective guidance of collective cell migration. Trends in Cell Biology 17 (12) : 575-579. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tcb.2007.09.007
dc.identifier.issn09628924
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/129660
dc.description.abstractSome cells migrate and find their way as solitary entities. However, during development of multicellular animals and possibly during tumor dissemination, cells often move as groups, associated tightly or loosely. Recent advances in live imaging have aided examination of such 'multicellular cell biology'. Here, I propose a model for how a group of cells can process and react to guidance information as a unit rather than as a gathering of solitary cells. Signaling pathways and regulatory mechanisms can differ substantially between solitary- and collective-guidance modes; a major difference being that, in collective guidance, similar to in bacterial chemotaxis, the signal need not be localized subcellularly within the responding cell. I suggest that collective-guidance signaling occurs alongside individual cell reactions. Both produce directional migration. © 2007 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.tcb.2007.09.007
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1016/j.tcb.2007.09.007
dc.description.sourcetitleTrends in Cell Biology
dc.description.volume17
dc.description.issue12
dc.description.page575-579
dc.description.codenTCBIE
dc.identifier.isiut000251738100002
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