Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tcb.2007.09.007
Title: Collective guidance of collective cell migration
Authors: Rørth, P. 
Issue Date: Dec-2007
Citation: Rørth, P. (2007-12). Collective guidance of collective cell migration. Trends in Cell Biology 17 (12) : 575-579. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tcb.2007.09.007
Abstract: Some cells migrate and find their way as solitary entities. However, during development of multicellular animals and possibly during tumor dissemination, cells often move as groups, associated tightly or loosely. Recent advances in live imaging have aided examination of such 'multicellular cell biology'. Here, I propose a model for how a group of cells can process and react to guidance information as a unit rather than as a gathering of solitary cells. Signaling pathways and regulatory mechanisms can differ substantially between solitary- and collective-guidance modes; a major difference being that, in collective guidance, similar to in bacterial chemotaxis, the signal need not be localized subcellularly within the responding cell. I suggest that collective-guidance signaling occurs alongside individual cell reactions. Both produce directional migration. © 2007 Elsevier Ltd. All rights reserved.
Source Title: Trends in Cell Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/129660
ISSN: 09628924
DOI: 10.1016/j.tcb.2007.09.007
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