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Title: Age-related reference intervals for free and total prostate-specific antigen in a Singaporean population
Authors: Saw, S.
Aw, T.-C. 
Keywords: Age
Prostate-specific antigen
Reference interval
Issue Date: 2000
Citation: Saw, S., Aw, T.-C. (2000). Age-related reference intervals for free and total prostate-specific antigen in a Singaporean population. Pathology 32 (4) : 245-249. ScholarBank@NUS Repository.
Abstract: Cancer of the prostate is the sixth most frequently found cancer in Singapore. Prostate-specific antigen (PSA) is the most clinically useful tumour marker available today for the diagnosis and management of prostate cancer. To enhance the value of PSA as a screening test we developed age-specific intervals for our ethnic population. The measurement of free PSA was included in the study to calculate the free:total ratio which enhances the differential diagnosis of prostate cancer from benign prostatic hyperplasia or prostatitis. The total PSA upper limits of 10-year intervals, beginning at 30-years-old, were 1.4, 1.7, 2.3, 4.0, 6.3 and 6.6 μg/l. Free PSA cut-off limits were 0.4, 0.5, 0.5, 1.0, 1.5 and 1.6 μg/l. The free:total ratio of PSA was not age dependent. Abbott AxSym standardised their calibration material for both free and total PSA assays with the Stanford 90:10 reference material. This laboratory has implemented these age-specific reference intervals and are currently following up their pick-up rate in the detection of prostate cancer.
Source Title: Pathology
ISSN: 00313025
Appears in Collections:Staff Publications

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