Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/129534
DC Field | Value | |
---|---|---|
dc.title | Biopsy-proved acute tubulointerstitial nephritis and toxic epidermal necrolysis associated with vancomycin | |
dc.contributor.author | Hsu, S.I.-H. | |
dc.date.accessioned | 2016-11-08T08:23:42Z | |
dc.date.available | 2016-11-08T08:23:42Z | |
dc.date.issued | 2001 | |
dc.identifier.citation | Hsu, S.I.-H. (2001). Biopsy-proved acute tubulointerstitial nephritis and toxic epidermal necrolysis associated with vancomycin. Pharmacotherapy 21 (10 I) : 1233-1239. ScholarBank@NUS Repository. | |
dc.identifier.issn | 02770008 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/129534 | |
dc.description.abstract | A 70-year-old man receiving vancomycin for a methicillin-resistant Staphylococcus aureus (MRSA) abscess developed a drug-induced hypersensitivity reaction with rash, eosinophilia, and acute renal failure requiring dialysis. Renal biopsy revealed diffuse and marked interstitial and tubular infiltration by mononuclear cells and eosinophils; acute tubulointerstitial nephritis (TIN) was diagnosed. The rash progressed to erythema multiforme major after rechallenge with vancomycin in the setting of MRSA peritoneal catheter-related peritonitis and then to fatal toxic epidermal necrolysis in the setting of steroid taper and persistent serum vancomycin levels. This case further implicates vancomycin as a drug that infrequently can cause severe acute TIN and exfoliative dermatitis. When a renally excreted drug such as vancomycin is administered, serum drug levels should be serially monitored and high-dosage steroids be maintained or tapered slowly until serum drug levels become undetectable. | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | MEDICINE | |
dc.description.sourcetitle | Pharmacotherapy | |
dc.description.volume | 21 | |
dc.description.issue | 10 I | |
dc.description.page | 1233-1239 | |
dc.description.coden | PHPYD | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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