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|Title:||Functional Characterization of Giant Killer in Flower Development and Meristem regulation in Arabidopsis Thaliana||Authors:||NG KIAN HONG||Keywords:||flower development, organ identity, patterning, differentiation, homeotic protein, nuclear organization||Issue Date:||14-Aug-2009||Citation:||NG KIAN HONG (2009-08-14). Functional Characterization of Giant Killer in Flower Development and Meristem regulation in Arabidopsis Thaliana. ScholarBank@NUS Repository.||Abstract:||The Arabidopsis homeotic protein AGAMOUS (AG) specifies reproductive organ identity during flower development. GIANT KILLER (GIK) was identified in this study as a direct target of AG. The GIK protein contains an AT-hook DNA binding motif that could bind to nuclear matrix attachment regions of DNA elements. Overexpression and loss of function of GIK caused wide-ranging defects in patterning and differentiation of reproductive organs and also disturbance of meristem regulation. GIK directly modulated the expression of several key transcriptional regulators, including ETTIN (ETT) and WUSCHEL (WUS). Overexpression of GIK resulted in a dynamic change of a repressive histone modification at the ETT and WUS promoters. GIK is suggested to act as a multifunctional chromatin organizer that could modulate and refine the expression of a large number of genes.||URI:||http://scholarbank.nus.edu.sg/handle/10635/12949|
|Appears in Collections:||Ph.D Theses (Open)|
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