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Title: Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease
Authors: Tan, E.K. 
Lee, J.
Chen, C.P. 
Wong, M.C.
Zhao, Y.
Keywords: Alzheimer's disease
Issue Date: Mar-2009
Citation: Tan, E.K., Lee, J., Chen, C.P., Wong, M.C., Zhao, Y. (2009-03). Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease. Neurobiology of Aging 30 (3) : 501-502. ScholarBank@NUS Repository.
Abstract: Alzheimer's disease (AD) pathology has been described in Parkinson's disease (PD) patients with leucine-rich repeat kinase-2 (LRRK2) mutations. A common LRRK2 Gly2385Arg variant has been widely shown to be associated with a twofold increased risk of PD in various Asian populations. In a case control study, the frequency of the heterozygous Gly2385Arg genotype was demonstrated in 4.3% of AD compared to 4.5% in controls (odds ratio = 0.94, 95% CI 0.37-2.42, p = 1.0). The Gly2385Arg variant does not appear to modulate the risk of AD in our population. © 2007 Elsevier Inc. All rights reserved.
Source Title: Neurobiology of Aging
ISSN: 01974580
DOI: 10.1016/j.neurobiolaging.2007.07.010
Appears in Collections:Staff Publications

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