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Title: Carteriosulfonic acids A-C, GSK-3β inhibitors from a Carteriospongia sp.
Authors: McCulloch, M.W.B.
Bugni, T.S.
Concepcion, G.P.
Coombs, G.S. 
Harper, M.K.
Kaur, S. 
Mangalindan, G.C.
Mutizwa, M.M.
Veltri, C.A.
Virshup, D.M. 
Ireland, C.M.
Issue Date: 25-Sep-2009
Citation: McCulloch, M.W.B., Bugni, T.S., Concepcion, G.P., Coombs, G.S., Harper, M.K., Kaur, S., Mangalindan, G.C., Mutizwa, M.M., Veltri, C.A., Virshup, D.M., Ireland, C.M. (2009-09-25). Carteriosulfonic acids A-C, GSK-3β inhibitors from a Carteriospongia sp.. Journal of Natural Products 72 (9) : 1651-1656. ScholarBank@NUS Repository.
Abstract: Modulators of Wnt signaling have therapeutic potential in a number of human diseases. A fractionated library from marine invertebrates was screened in a luciferase assay designed to identify modulators of Wnt signaling. A fraction from a Carteriospongia sp. sponge activated Wnt signaling and was subsequently shown to inhibit GSK-3β, which inhibits Wnt signaling through phosphorylation of β-catenin. Three novel natural products, carteriosulfonic acids A (1), B (2), and C (3), were identified as active constituents. The carteriosulfonic acids contain unprecedented 4,6,7,9-tetrahydroxylated decanoic acid subunits. Their structures were elucidated through analysis of NMR data and a detailed analysis of pseudo MS3 spectra. © 2009 American Chemical Society and American Society of Pharmacognosy.
Source Title: Journal of Natural Products
ISSN: 01633864
DOI: 10.1021/np900336f
Appears in Collections:Staff Publications

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