Please use this identifier to cite or link to this item:
|Title:||Carteriosulfonic acids A-C, GSK-3β inhibitors from a Carteriospongia sp.||Authors:||McCulloch, M.W.B.
|Issue Date:||25-Sep-2009||Citation:||McCulloch, M.W.B., Bugni, T.S., Concepcion, G.P., Coombs, G.S., Harper, M.K., Kaur, S., Mangalindan, G.C., Mutizwa, M.M., Veltri, C.A., Virshup, D.M., Ireland, C.M. (2009-09-25). Carteriosulfonic acids A-C, GSK-3β inhibitors from a Carteriospongia sp.. Journal of Natural Products 72 (9) : 1651-1656. ScholarBank@NUS Repository. https://doi.org/10.1021/np900336f||Abstract:||Modulators of Wnt signaling have therapeutic potential in a number of human diseases. A fractionated library from marine invertebrates was screened in a luciferase assay designed to identify modulators of Wnt signaling. A fraction from a Carteriospongia sp. sponge activated Wnt signaling and was subsequently shown to inhibit GSK-3β, which inhibits Wnt signaling through phosphorylation of β-catenin. Three novel natural products, carteriosulfonic acids A (1), B (2), and C (3), were identified as active constituents. The carteriosulfonic acids contain unprecedented 4,6,7,9-tetrahydroxylated decanoic acid subunits. Their structures were elucidated through analysis of NMR data and a detailed analysis of pseudo MS3 spectra. © 2009 American Chemical Society and American Society of Pharmacognosy.||Source Title:||Journal of Natural Products||URI:||http://scholarbank.nus.edu.sg/handle/10635/129468||ISSN:||01633864||DOI:||10.1021/np900336f|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 20, 2020
WEB OF SCIENCETM
checked on Feb 12, 2020
checked on Feb 21, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.