Please use this identifier to cite or link to this item:
DC FieldValue
dc.titleAltered fibrinolysis in DVT: Influence of site of sampling
dc.contributor.authorHan, P.
dc.contributor.authorKoay, E.S.C.
dc.contributor.authorTsakok, M.
dc.contributor.authorAw, T.C.
dc.contributor.authorWong, L.Y.
dc.contributor.authorPradhan, M.
dc.identifier.citationHan, P.,Koay, E.S.C.,Tsakok, M.,Aw, T.C.,Wong, L.Y.,Pradhan, M. (1988). Altered fibrinolysis in DVT: Influence of site of sampling. Thrombosis and Haemostasis 60 (1) : 50-53. ScholarBank@NUS Repository.
dc.description.abstractAlteration of the fibrinolytic system is considered to be important in the development of deep venous thrombosis (DVT). Using specific assays for tissue plasminogen activator (t-PA) activity, t-PA inhibitor (PAI) and t-PA antigen, we measured these activities in 16 women who developed DVT during their pregnancies. A group of 24 healthy females of comparable age was studied as controls. PAI was increased in 87% of these patients compared to the healthy controls. In some of these patients a defect in release of t-PA from vascular endothelium was found as well. The site at which blood was sampled for analysis appeared to be an important criterion in the ex vivo assessment of functional t-PA reserve and PAI levels, though relatively less so for the latter measurement. The unaffected lower limbs, relative to the unaffected upper limbs, showed an increase in PAI and a demonstrable decrease in t-PA release, both representing increased risk factors for rethrombosis. The affected lower limbs showed similar but more accentuated changes in these parameters.
dc.description.sourcetitleThrombosis and Haemostasis
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Page view(s)

checked on Jan 27, 2022

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.