Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/129216
DC Field | Value | |
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dc.title | Altered fibrinolysis in DVT: Influence of site of sampling | |
dc.contributor.author | Han, P. | |
dc.contributor.author | Koay, E.S.C. | |
dc.contributor.author | Tsakok, M. | |
dc.contributor.author | Aw, T.C. | |
dc.contributor.author | Wong, L.Y. | |
dc.contributor.author | Pradhan, M. | |
dc.date.accessioned | 2016-11-02T03:18:09Z | |
dc.date.available | 2016-11-02T03:18:09Z | |
dc.date.issued | 1988 | |
dc.identifier.citation | Han, P.,Koay, E.S.C.,Tsakok, M.,Aw, T.C.,Wong, L.Y.,Pradhan, M. (1988). Altered fibrinolysis in DVT: Influence of site of sampling. Thrombosis and Haemostasis 60 (1) : 50-53. ScholarBank@NUS Repository. | |
dc.identifier.issn | 03406245 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/129216 | |
dc.description.abstract | Alteration of the fibrinolytic system is considered to be important in the development of deep venous thrombosis (DVT). Using specific assays for tissue plasminogen activator (t-PA) activity, t-PA inhibitor (PAI) and t-PA antigen, we measured these activities in 16 women who developed DVT during their pregnancies. A group of 24 healthy females of comparable age was studied as controls. PAI was increased in 87% of these patients compared to the healthy controls. In some of these patients a defect in release of t-PA from vascular endothelium was found as well. The site at which blood was sampled for analysis appeared to be an important criterion in the ex vivo assessment of functional t-PA reserve and PAI levels, though relatively less so for the latter measurement. The unaffected lower limbs, relative to the unaffected upper limbs, showed an increase in PAI and a demonstrable decrease in t-PA release, both representing increased risk factors for rethrombosis. The affected lower limbs showed similar but more accentuated changes in these parameters. | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | PAEDIATRICS | |
dc.contributor.department | BIOCHEMISTRY | |
dc.description.sourcetitle | Thrombosis and Haemostasis | |
dc.description.volume | 60 | |
dc.description.issue | 1 | |
dc.description.page | 50-53 | |
dc.description.coden | THHAD | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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