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|Title:||Biological activity and anti-prostaglandin effects of prostaglandin analogue, ent-11-epi-15-epi PGE2 methyl ester||Authors:||Adaikan, P.
|Issue Date:||Jan-1990||Citation:||Adaikan, P.,Lau, L.,Chua, Y.,Ratnam, S. (1990-01). Biological activity and anti-prostaglandin effects of prostaglandin analogue, ent-11-epi-15-epi PGE2 methyl ester. Prostaglandins, Leukotrienes and Essential Fatty Acids 39 (1) : 91-94. ScholarBank@NUS Repository.||Abstract:||The biological activity and anti-prostaglandin property of the prostaglandin analogue, ent-11-epi-15-epi PGE2 methyl ester, were studied on isolated guinea pig ileum. Ent-11-epi-15-epi PGE2 methyl ester contracted guinea pig ileum and produced a concentration-response curve parallel to that of PGE2. However, the former exhibited a lower maximal effect than PGE2. At concentrations > 10-6M, ent-11-epi-15-epi PGE2 methyl ester selectively antagonized contractile actions of PGE2 and PGE2α without affecting contractions induced by acetylcholine. These observations suggest that the PG analogue acted like a competitive antagonist to PGE2 and PGF2α on guinea pig ileum in vitro. © 1990.||Source Title:||Prostaglandins, Leukotrienes and Essential Fatty Acids||URI:||http://scholarbank.nus.edu.sg/handle/10635/129203||ISSN:||09523278|
|Appears in Collections:||Staff Publications|
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