Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/129203
Title: Biological activity and anti-prostaglandin effects of prostaglandin analogue, ent-11-epi-15-epi PGE2 methyl ester
Authors: Adaikan, P. 
Lau, L. 
Chua, Y.
Ratnam, S. 
Issue Date: Jan-1990
Citation: Adaikan, P.,Lau, L.,Chua, Y.,Ratnam, S. (1990-01). Biological activity and anti-prostaglandin effects of prostaglandin analogue, ent-11-epi-15-epi PGE2 methyl ester. Prostaglandins, Leukotrienes and Essential Fatty Acids 39 (1) : 91-94. ScholarBank@NUS Repository.
Abstract: The biological activity and anti-prostaglandin property of the prostaglandin analogue, ent-11-epi-15-epi PGE2 methyl ester, were studied on isolated guinea pig ileum. Ent-11-epi-15-epi PGE2 methyl ester contracted guinea pig ileum and produced a concentration-response curve parallel to that of PGE2. However, the former exhibited a lower maximal effect than PGE2. At concentrations > 10-6M, ent-11-epi-15-epi PGE2 methyl ester selectively antagonized contractile actions of PGE2 and PGE2α without affecting contractions induced by acetylcholine. These observations suggest that the PG analogue acted like a competitive antagonist to PGE2 and PGF2α on guinea pig ileum in vitro. © 1990.
Source Title: Prostaglandins, Leukotrienes and Essential Fatty Acids
URI: http://scholarbank.nus.edu.sg/handle/10635/129203
ISSN: 09523278
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

38
checked on Jun 21, 2019

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.