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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neulet.2013.12.057
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dc.titleCo-localization of L-type voltage dependent calcium channel alpha 1D subunit (Cav1.3) and calbindin (CB) in the mouse central nervous system
dc.contributor.authorXu, J.H.
dc.contributor.authorYang, Z.B.
dc.contributor.authorWang, H.
dc.contributor.authorTang, F.-R.
dc.date.accessioned2016-10-22T07:45:41Z
dc.date.available2016-10-22T07:45:41Z
dc.date.issued2014-02-21
dc.identifier.citationXu, J.H., Yang, Z.B., Wang, H., Tang, F.-R. (2014-02-21). Co-localization of L-type voltage dependent calcium channel alpha 1D subunit (Cav1.3) and calbindin (CB) in the mouse central nervous system. Neuroscience Letters 561 : 80-85. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neulet.2013.12.057
dc.identifier.issn03043940
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/128905
dc.description.abstractPrevious study has shown that the co-localization of calbindin (CB) with L-type voltage dependent Ca2+ channel (VDCC) alpha 1C subunit (Cav1.2) in the rat insulinoma 1046-38 (RIN) beta cells may play an important regulatory role in Ca2+ influx and exocytosis of insulin granules. In the present study, L-type voltage dependent Ca2+ channel (VDCC) and calbindin (CB) were demonstrated in different regions of the mouse central nervous system (CNS). Double labeling immunofluorescence staining showed a co-localization of Cav1.3 and CB. The co-localization of Cav1.3 and CB in certain brain regions such as the hippocampus suggests their important roles in neuroplasticity. The relative high percentages of co-localization of Cav1.3 with CB in the laminae II of the dorsal horn of the spinal cord indicate that the regulation mechanism of nociceptive transmission may be related with both VDCC and Ca2+ binding protein. © 2013 Elsevier Ireland Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.neulet.2013.12.057
dc.sourceScopus
dc.subjectCav1.3
dc.subjectCB
dc.subjectCentral nervous system
dc.subjectCo-localization
dc.typeArticle
dc.contributor.departmentTEMASEK LABORATORIES
dc.description.doi10.1016/j.neulet.2013.12.057
dc.description.sourcetitleNeuroscience Letters
dc.description.volume561
dc.description.page80-85
dc.description.codenNELED
dc.identifier.isiut000331858100015
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