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Title: Longitudinal Changes of Angle Configuration in Primary Angle-Closure Suspects. The Zhongshan Angle-Closure Prevention Trial
Authors: Jiang, Y.
Chang, D.S.
Zhu, H.
Khawaja, A.P.
Aung, T. 
Huang, S.
Chen, Q.
Munoz, B.
Grossi, C.M.
He, M.
Friedman, D.S.
Foster, P.J.
Issue Date: 2014
Citation: Jiang, Y., Chang, D.S., Zhu, H., Khawaja, A.P., Aung, T., Huang, S., Chen, Q., Munoz, B., Grossi, C.M., He, M., Friedman, D.S., Foster, P.J. (2014). Longitudinal Changes of Angle Configuration in Primary Angle-Closure Suspects. The Zhongshan Angle-Closure Prevention Trial. Ophthalmology. ScholarBank@NUS Repository.
Abstract: Objective: To determine longitudinal changes in angle configuration in the eyes of primary angle-closure suspects (PACS) treated by laser peripheral iridotomy (LPI) and in untreated fellow eyes. Design: Longitudinal cohort study. Participants: Primary angle-closure suspects aged 50 to 70 years were enrolled in a randomized, controlled clinical trial. Methods: Each participant was treated by LPI in 1 randomly selected eye, with the fellow eye serving as a control. Angle width was assessed in a masked fashion using gonioscopy and anterior segment optical coherence tomography (AS-OCT) before and at 2 weeks, 6 months, and 18 months after LPI. Main Outcome Measures: Angle width in degrees was calculated from Shaffer grades assessed under static gonioscopy. Angle configuration was also evaluated using angle opening distance (AOD250, AOD500, AOD750), trabecular-iris space area (TISA500, TISA750), and angle recess area (ARA) measured in AS-OCT images. Results: No significant difference was found in baseline measures of angle configuration between treated and untreated eyes. At 2 weeks after LPI, the drainage angle on gonioscopy widened from a mean of 13.5° at baseline to a mean of 25.7° in treated eyes, which was also confirmed by significant increases in all AS-OCT angle width measures (P
Source Title: Ophthalmology
ISSN: 01616420
DOI: 10.1016/j.ophtha.2014.03.039
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